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Cistobislactones A-B, two sixteen-membered spiro-linked macrocylic bislactones from marine octopus Cistopus indicus: new antiinflammatory agents attenuate arachidonate 5-lipoxygenase

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Relation http://eprints.cmfri.org.in/15333/
https://doi.org/10.1080/14786419.2021.1938041
https://doi.org/10.1080/14786419.2021.1938041
 
Title Cistobislactones A-B, two sixteen-membered spiro-linked macrocylic bislactones from marine octopus Cistopus indicus: new antiinflammatory agents attenuate arachidonate 5-lipoxygenase
 
Creator Silpa, K P
Chakraborty, Kajal
 
Subject Fish Genetics
 
Description Biochemical analysis of secondary metabolites of marine old-woman octopus Cistopus indicus (family Octopodidae) led to the identification of two sixteen-membered spiro-linked macrocyclic bislactones, named as cistobislactone A and cistobislactone B with unprecedented feature of henicos framework, based on extensive spectroscopic analyses. Cistobislactone B exhibited potential inhibition property against arachidonate 5-lipoxygenase (IC50 2.18 mM) than that demonstrated by cistobislactone A (IC50 2.54 mM) and standard non-steroidal anti-inflammatory agent ibuprofen (IC50 4.50 mM) thus signifying the higher anti-inflammatory activity of the cistobislactone B analogue.
 
Date 2021-08-25
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/15333/1/2%29%20Cistobislactones%20A-B%2C%20two%20sixteen-membered%20spiro-linked%20macrocylic%20bislactones%20from%20marine%20octopus.pdf
Silpa, K P and Chakraborty, Kajal (2021) Cistobislactones A-B, two sixteen-membered spiro-linked macrocylic bislactones from marine octopus Cistopus indicus: new antiinflammatory agents attenuate arachidonate 5-lipoxygenase. Natural Product Research. pp. 1-11.