Cistobislactones A-B, two sixteen-membered spiro-linked macrocylic bislactones from marine octopus Cistopus indicus: new antiinflammatory agents attenuate arachidonate 5-lipoxygenase
CMFRI Repository
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Relation |
http://eprints.cmfri.org.in/15333/
https://doi.org/10.1080/14786419.2021.1938041 https://doi.org/10.1080/14786419.2021.1938041 |
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Title |
Cistobislactones A-B, two sixteen-membered spiro-linked macrocylic bislactones from marine octopus Cistopus indicus: new antiinflammatory agents attenuate arachidonate 5-lipoxygenase
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Creator |
Silpa, K P
Chakraborty, Kajal |
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Subject |
Fish Genetics
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Description |
Biochemical analysis of secondary metabolites of marine old-woman octopus Cistopus indicus (family Octopodidae) led to the identification of two sixteen-membered spiro-linked macrocyclic bislactones, named as cistobislactone A and cistobislactone B with unprecedented feature of henicos framework, based on extensive spectroscopic analyses. Cistobislactone B exhibited potential inhibition property against arachidonate 5-lipoxygenase (IC50 2.18 mM) than that demonstrated by cistobislactone A (IC50 2.54 mM) and standard non-steroidal anti-inflammatory agent ibuprofen (IC50 4.50 mM) thus signifying the higher anti-inflammatory activity of the cistobislactone B analogue.
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Date |
2021-08-25
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Type |
Article
PeerReviewed |
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Format |
text
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Language |
en
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Identifier |
http://eprints.cmfri.org.in/15333/1/2%29%20Cistobislactones%20A-B%2C%20two%20sixteen-membered%20spiro-linked%20macrocylic%20bislactones%20from%20marine%20octopus.pdf
Silpa, K P and Chakraborty, Kajal (2021) Cistobislactones A-B, two sixteen-membered spiro-linked macrocylic bislactones from marine octopus Cistopus indicus: new antiinflammatory agents attenuate arachidonate 5-lipoxygenase. Natural Product Research. pp. 1-11. |
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