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Callypyrones from marine Callyspongiidae sponge Callyspongia diffusa: antihypertensive bis-c-pyrone polypropionates attenuate angiotensin-converting enzyme

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Relation http://eprints.cmfri.org.in/15394/
https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1837819?journalCode=gnpl20
10.1080/14786419.2020.1837819
 
Title Callypyrones from marine Callyspongiidae sponge
Callyspongia diffusa: antihypertensive bis-c-pyrone
polypropionates attenuate angiotensin-converting enzyme
 
Creator Chakraborty, Kajal
Francis, Prima
 
Subject Bioactive compounds
Biochemical composition
Biochemistry
 
Description Angiotensin I-converting enzyme (ACE) catalyses the biosynthesis
of angiotensin II, a potent blood vessel constrictor, from angiotensin I, and ACE inhibitors were recognised as medications for
hypertension. Undescribed bis-c-pyrone polypropionate compounds, callypyrones A and B were purified from the organic
extract of Callyspongiidae sponge species Callyspongia diffusa by
repeated chromatographic purification. Callypyrone A exhibited
significantly greater attenuation potential against ACE (IC50
0.48 mM) than that displayed by callypyrone B (IC50 0.57 mM) and
showed comparable activity with standard ACE inhibitor captopril
(IC50 0.36 mM). Higher electronic parameters of callypyrone A
(topological surface area of 108.36) combined with balanced
hydrophilic-lipophilic parameter (octanol–water coefficient, log
Pow 1.9), as deduced from the structure–activity relationship analyses, could further indicate the improved ligand–receptor interactions resulting in its prospective ACE inhibitory activity. In silico
docking analyses of the callypyrones with ACE recorded lowest
binding energy (–12.58 kcal mol-1
) for callypyrone A, which further supported the antihypertensive potential of the compound
 
Publisher Taylor and Francis
 
Date 2020
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/15394/1/Natural%20product%20research_2020_Kajal%20Chakraborty_Callypyrones.pdf
Chakraborty, Kajal and Francis, Prima (2020) Callypyrones from marine Callyspongiidae sponge Callyspongia diffusa: antihypertensive bis-c-pyrone polypropionates attenuate angiotensin-converting enzyme. Natural Product Research. pp. 1-12.