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Clathriolide from marine demosponge Clathria (Thalysias) vulpina (Lamarck, 1814): previously undescribed macrocylic lactone with attenuating potential against angiotensin converting enzyme

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Relation http://eprints.cmfri.org.in/15396/
https://www.tandfonline.com/doi/abs/10.1080/14786419.2021.1887177?journalCode=gnpl20
10.1080/14786419.2021.1887177
 
Title Clathriolide from marine demosponge Clathria (Thalysias)
vulpina (Lamarck, 1814): previously undescribed
macrocylic lactone with attenuating potential against
angiotensin converting enzyme
 
Creator Chakraborty, Kajal
Francis, Prima
 
Subject Bioactive compounds
Biochemical composition
Biochemistry
 
Description Angiotensin-I converting enzyme catalyses the rate-determined
step of the conversion of angiotensin-I to angiotensin-II that narrows the blood vessels, and angiotensin-I converting enzyme
inhibitors were recognised as important medications for hypertension-related diseases. Chemical investigation of angiotensin-I converting enzyme inhibitors from marine demospongiae Clathria
(Thalysias) vulpina (family Microcionidae), resulted in a previously
undescribed 22-membered macrocyclic lactone derivative, named
as clathriolide. The studied compound showed potential angiotensin converting enzyme attenuation property (IC50 0.41 mM),
which was comparable with the standard captopril (IC50 0.36 mM).
Clathriolide revealed significantly greater antioxidant potentials
against free radical species (IC50 < 1 mM) in comparison with the
standard a-tocopherol (IC50 > 1.5 mM). Superior electronic characteristics (topological polar surface area > 100) coupled with relatively smaller binding energy and docking score of clathriolide
with the aminoacyl residues of angiotensin-I converting enzyme
(–11.5 and –12.2 kcal/mol, respectively) described its potential
inhibitory property against angiotensin-I converting enzyme.
 
Publisher Taylor and Francis
 
Date 2021
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/15396/1/Natural%20product%20research_2021_Kajal%20Chakraborty.pdf
Chakraborty, Kajal and Francis, Prima (2021) Clathriolide from marine demosponge Clathria (Thalysias) vulpina (Lamarck, 1814): previously undescribed macrocylic lactone with attenuating potential against angiotensin converting enzyme. Natural Product Research. pp. 1-10.