Record Details

Hyrtioscalaranes A and B, two new scalarane-type sesterterpenes from Hyrtios erectus with anti-inflammatory and antioxidant effec

CMFRI Repository

View Archive Info
 
 
Field Value
 
Relation http://eprints.cmfri.org.in/15397/
https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1795854?journalCode=gnpl20
10.1080/14786419.2020.1795854
 
Title Hyrtioscalaranes A and B, two new scalarane-type
sesterterpenes from Hyrtios erectus with anti-inflammatory and antioxidant effec
 
Creator Chakraborty, Kajal
Francis, Prima
 
Subject Bioactive compounds
Biochemical composition
Biochemistry
 
Description Two new scalarane-type sesterterpenes, hyrtioscalaranes A and B,
were isolated from the organic extract of the Demosponge
Hyrtios erectus through extensive chromatographic purification.
Hyrtioscalarane A exhibited significantly greater attenuation property against cyclooxygense-2 (IC50 0.83 mM) than that displayed
by hyrtioscalarane B (IC50 0.98 mM). The greater selectivity index
of hyrtioscalaranes (> 1) than that exhibited by the commercial
anti-inflammatory agent ibuprofen (0.43) further supported the
higher selectivity of the former towards pro-inflammatory cyclooxygenase-2. Hyrtioscalarane A exhibited greater antioxidant activities as determined by 2,2’-azino-bis(3-ethylbenzothiazoline-6-
sulphonic acid) (IC50 0.77 mM) and 2,2-diphenyl-1-picrylhydrazyl
(IC50 0.81 mM) free radical quenching properties than those displayed by hyrtioscalarane B (IC50 > 0.83 mM) and the antioxidative agent a-tocopherol (IC50 1.51 mM). The greater binding
energy (–14.32 kcal/mol) and docking score (15.22 kcal/mol) of
hyrtioscalarane A at the active site of cyclooxygenase-2 along
with the higher electronic parameters and balanced hydrophobicity could attribute its potential anti-inflammatory activity.
 
Publisher Taylor and Francis
 
Date 2020
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/15397/1/Natural%20product%20reserach_2020_Kajal%20Chakraborty_%20Hyrtios%20erectus.pdf
Chakraborty, Kajal and Francis, Prima (2020) Hyrtioscalaranes A and B, two new scalarane-type sesterterpenes from Hyrtios erectus with anti-inflammatory and antioxidant effec. Natural Product Research. pp. 1-12.