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Erectcyanthins A-C from marine sponge Hyrtios erectus: anti-dyslipidemic agents attenuate hydroxymethylglutaryl coenzyme A reductase

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Relation http://eprints.cmfri.org.in/15588/
https://www.tandfonline.com/doi/full/10.1080/14786419.2021.2013216
10.1080/14786419.2021.2013216
 
Title Erectcyanthins A-C from marine sponge Hyrtios erectus: anti-dyslipidemic agents attenuate hydroxymethylglutaryl coenzyme A reductase
 
Creator Chakraborty, Kajal
Francis, Prima
 
Subject Biochemistry
Algae
 
Description Bioactivity-steered chromatographic purification of the solvent extract of marine sponge Hyrtios erectus (Thorectidae) led to the isolation of three undescribed cyanthiwigin-type diterpenoids, erectcyanthins A-C. Erectcyanthin B exhibited comparable attenuation activity against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (IC50 0.07 mM) with that displayed by anti-dyslipidemic
agent atorvastatin (IC50 0.08 mM). Comparatively greater antioxidant properties of erectcyanthin B (IC50 0.4 mM) than that displayed by erectcyanthin A (IC50 0.5 mM), erectcyanthin C and the standard a-tocopherol (IC50 1.5–1.7 mM) against oxidants also corroborated its promising bioactivity. Erectcyanthin B exhibited considerably greater anti-inflammatory activities (IC50 0.88–1.09 mM) than other erectcyanthin analogues in the series. The potential anti-dyslipidemic activity of erectcyanthins was linearly correlated with electronic parameter (topological polar surface area 74.6) along with balanced hydrophilic-lipophilic properties (logarithmic octanol-water partition coefficient 1.76). This study recognized the anti-dyslipidemic property of erectcyanthin B as a promising pharmaceutical lead.
 
Publisher Taylor and Francis
 
Date 2021
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/15588/1/Natural%20product%20research_2021_Kajal%20Chakraborty.pdf
Chakraborty, Kajal and Francis, Prima (2021) Erectcyanthins A-C from marine sponge Hyrtios erectus: anti-dyslipidemic agents attenuate hydroxymethylglutaryl coenzyme A reductase. Natural Product Research. pp. 1-12. ISSN 1478-6427 (Online)