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Marine-derived polygalactofucan and its β-2-deoxy-aminosubstituted glucopyranan composite attenuate 3-hydroxy-3- methylglutaryl-CoA reductase: prospective natural anti-dyslipidemic leads

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Relation http://eprints.cmfri.org.in/14049/
https://link.springer.com/article/10.1007%2Fs00044-019-02482-7
https://doi.org/10.1007/s00044-019-02482-7
 
Title Marine-derived polygalactofucan and its β-2-deoxy-aminosubstituted
glucopyranan composite attenuate 3-hydroxy-3-
methylglutaryl-CoA reductase: prospective natural anti-dyslipidemic
leads
 
Creator Chakraborty, Kajal
Anusree, M
 
Subject Bioactive compound
Bioprospecting
Biochemistry
 
Description Adverse side effects reported for the use of statin drugs provided insights to develop potential anti-dyslipidemic derivatives
from natural origin. The objective of the work was to develop the marine-derived polysaccharides attenuating 3-hydroxy-3-
methylglutaryl-CoA reductase (HMGCR), and as prospective natural anti-dyslipidemic leads. Physical and chromatographic
purification methods were used to isolate the polygalactofucan from the marine macroalga Sargassum wightii and β-(2-
deoxy)-amino-substituted glucopyrananan from a marine crustacean. Glycosidic linkage analysis by the process of
methylation was used for structural elucidation of the polygalactofucan, and the methylated and partially methylated alditol
acetates were characterized using extensive spectroscopic experiments. The polysaccharide composite constituting the titled
polysaccharide motifs showed significant HMGCR inhibitory potential (IC90 0.12 mg mL−1) and an increase in HMG-CoA/
mevalonate ratio (1.68 mg dL−1) compared with the high-fat diet (HFD)-treated animals (1.04 mg dL−1), which recognized
its hypo-lipidemic efficacy. In vivo results demonstrated about 70% reduction in the triglyceride levels with the concomitant
increase (~39%) of hepatic lipoprotein lipase (LPL) activity in the HFD-fed Wistar rats treated with 500 mg kg−1 body
weight. The results illustrated the use of marine-derived polygalactofucan composite as potential anti-dyslipidemic agent.
 
Date 2020
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/14049/1/Medicinal%20Chemistry%20Research_2019_Kajal%20Chakraborty_Marine-derived%20polygalactofucan.pdf
Chakraborty, Kajal and Anusree, M (2020) Marine-derived polygalactofucan and its β-2-deoxy-aminosubstituted glucopyranan composite attenuate 3-hydroxy-3- methylglutaryl-CoA reductase: prospective natural anti-dyslipidemic leads. Medicinal Chemistry Research, 29 (2). pp. 281-300.