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Undescribed Anti-Inflammatory Thalysiaketides from Marine Sponge Clathria (Thalysias) vulpina (Lamarck, 1814)

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Relation http://eprints.cmfri.org.in/15769/
https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202100838
https://doi.org/10.1002/cbdv.202100838
 
Title Undescribed Anti-Inflammatory Thalysiaketides from Marine Sponge Clathria (Thalysias) vulpina (Lamarck, 1814)
 
Creator Francis, Prima
Chakraborty, Kajal
 
Subject Biochemistry
Sponges
 
Description Two undescribed polyketide-type compounds, thalysiaketide A and thalysiaketide B were isolated from a sponge of marine origin Clathria (Thalysias) vulpina (Lamarck, 1814). Thalysiaketide A exhibited significantly greater inhibitory potential against inflammatory 5-lipoxygenase (IC50 0.87 mM) and cyclooxygense-2 (IC500.93 mM) compared to those displayed by its thalysiaketide B analog (IC501.05 mM). The 5-lipoxygenase inhibitory activity of thalysiaketide A was considerably superior to ibuprofen (standard, IC50>4 mM). Higher degree of polar belongings (topological polar surface area 93.06) in conjunction with relatively lower docking parameters of thalysiaketide A with the aminoacyl residues of cyclooxygense-2 and 5-lipoxygenase (docking score 12.99 and 12.27 kcal/mol, respectively) recognized its prospective anti-inflammatory potential
 
Publisher Wiley
 
Date 2022
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/15769/1/Chemistry%20and%20Biodiversity_2022_Kajal%20Chakraborty.pdf
Francis, Prima and Chakraborty, Kajal (2022) Undescribed Anti-Inflammatory Thalysiaketides from Marine Sponge Clathria (Thalysias) vulpina (Lamarck, 1814). Chemistry and Biodiversity. pp. 1-8.