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Antioxidant and antiinflammatory secondary metabolites from the Asian green mussel Perna viridis

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Relation http://eprints.cmfri.org.in/13622/
https://onlinelibrary.wiley.com/doi/10.1111/jfbc.12736
https://doi.org/10.1111/jfbc.12736
 
Title Antioxidant and antiinflammatory secondary metabolites from the Asian green mussel Perna viridis
 
Creator Chakraborty, Kajal
Joy, Minju
Chakkalakal, Selsa Jose
 
Subject Bioactive compound
Mussel culture
Fish Biotechnology
 
Description The Asian green mussel, Perna viridis is a nutritious health food in the estuarine and coastal sea beds of the Arabian Sea along the west coast of India. In the present study, bioactivity‐guided purification of the chloroform fraction of the methanolic extract of P. viridis was carried out. The isolated secondary metabolites were characterized by spectroscopic experiments, and their antioxidative/antiinflammatory properties were evaluated. The titled compounds were characterized as 3‐hydroxy‐13‐vinyl‐dodecahydro‐11‐phenanthrenone (1), 4,4,9‐trimethyl‐13‐vinyl‐dodecahydro‐2‐phenanthrenone (2), 11,20‐dihydroxy‐6,6‐dimethyl‐decahydro‐5H‐benzo[h]naphtho[1,2‐c]chromene‐16‐carbaldehyde (3), 16‐acetyl‐20‐hydroxy‐6,6‐dimethyl‐dodecahydro‐5H‐benzo[h]naphtho[1,2‐c]chromen‐12‐one (4), cholest‐5‐en‐3β‐3‐yl‐(30‐hydroxy‐3‐methyl‐36‐methyleneundeca‐30E,34E‐dienoate) (5), and cholest‐5‐en‐3β‐3‐yl‐((E)‐33‐oxooct‐31‐enoate) (6). No significant differences in the antioxidant activities of the compounds with chromene‐16‐carbaldehyde (3) and chromen‐12‐one (4) functionalities (IC50 0.52–0.68 mg/ml) vis‐à‐vis the positive control, α‐tocopherol (IC50 0.65–0.76 mg/ml) were registered. The studied compounds, 1–4, displayed potential antiinflammatory activities against pro‐inflammatory 5‐lipoxygenase (5‐LOX) (IC50 < 1 mg/ml). The balanced hydrophilic–lipophilic properties and lower steric values of the studied compounds, 1–4, were correlated with their bioactive potentials.
 
Date 2019
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/13622/1/Journal%20of%20Food%20Biochemistry_2018_Kajal%20Chakraborty_Antioxidant%20and%20antiinflammatory%20secondary%20metabolites.pdf
Chakraborty, Kajal and Joy, Minju and Chakkalakal, Selsa Jose (2019) Antioxidant and antiinflammatory secondary metabolites from the Asian green mussel Perna viridis. Journal of Food Biochemistry, 43 (3). pp. 1-12.