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Antioxidant drimane‐type sesquiterpenoid from muricid gastropod Chicoreus ramosus attenuates pro‐inflammatory 5‐lipoxygenase and carbolytic enzymes

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Relation http://eprints.cmfri.org.in/13957/
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jfbc.12991
DOI: 10.1111/jfbc.12991
 
Title Antioxidant drimane‐type sesquiterpenoid from muricid
gastropod Chicoreus ramosus attenuates pro‐inflammatory
5‐lipoxygenase and carbolytic enzymes
 
Creator Chakraborty, Kajal
Salas, Soumya
 
Subject Bioactive compound
Fish Biotechnology
 
Description The muricid gastropod, Chicoreus ramosus, is a nutrient‐enriched food source available
along the coastal peninsular of the Indian subcontinent. This study was aimed at
bioactivity‐directed chromatographic fractionation of the organic extract of C. ramosus
to isolate an unprecedented drimane‐type sesquiterpenoid Ramosane, characterized
as 3‐hydroxy‐7,9b‐dimethyl‐5‐methylene‐8‐pentyl‐octahydro‐1H‐cyclopenta[a]
naphthalen‐9(2H)‐one. The compound possessed potential antioxidant activities {2,
2′‐diphenyl‐1‐picryl hydrazyl (DPPH) and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐
sulfonic acid (ABTS) radical scavenging activities of IC50 1.42 mM and 1.72 mM, respectively}
and was proportionate with those (IC50 1.39 and 1.69 mM, respectively)
exhibited by α‐tocopherol. The studied sesquiterpenoid exhibited potential attenuation
property countering the pro‐inflammatory 5‐lipoxygenase (IC50 ~ 4 mM), and its
activity was analogous with that exhibited by the anti‐inflammatory ibuprofen (IC50
4.36 mM), whereas its carbolytic α‐amylase activity (IC50 0.96 mM) was commensurate
with that displayed by acarbose (IC50 0.43 mM). The isolated metabolite might
anticipate as potential naturally derived bioactive constituent in functional food and
pharmaceutical applications.
 
Date 2019
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/13957/1/Journal%20of%20Food%20Biochemistry_2019_Kajal%20Chakraborty_Antioxidant%20drimane%E2%80%90type%20sesquiterpenoid%20from%20muricid%20gastropod%20Chicoreus%20ramosus.pdf
Chakraborty, Kajal and Salas, Soumya (2019) Antioxidant drimane‐type sesquiterpenoid from muricid gastropod Chicoreus ramosus attenuates pro‐inflammatory 5‐lipoxygenase and carbolytic enzymes. Journal of Food Biochemistry. pp. 1-8. ISSN 1745–4514