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Leap Forward towards Unraveling Newer Anti‑infective Agents from an Unconventional Source: a Draft Genome Sequence Illuminating the Future Promise of Marine Heterotrophic Bacillus sp. Against Drug‑Resistant Pathogens

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Relation http://eprints.cmfri.org.in/15346/
https://link.springer.com/article/10.1007%2Fs10126-021-10064-1
https://doi.org/10.1007/s10126-021-10064-1
 
Title Leap Forward towards Unraveling Newer Anti‑infective Agents
from an Unconventional Source: a Draft Genome Sequence
Illuminating the Future Promise of Marine Heterotrophic Bacillus sp.
Against Drug‑Resistant Pathogens
 
Creator Chakraborty, Kajal
Vinaya, K K
Joy, Minju
Chakraborty, Rekha D
 
Subject Bioactive compounds
Biochemistry
Algae
 
Description During the previous decade, genome-built researches on marine heterotrophic microorganisms displayed the chemical heterogeneity of natural product resources coupled with the efcacies of harnessing the genetic divergence in various strains. Herein,
we describe the whole genome data of heterotrophic Bacillus amyloliquefaciens MB6 (MTCC 12,716), isolated from a marine
macroalga Hypnea valentiae, a 4,107,511-bp circular chromosome comprising 186 contigs, with 4154 protein-coding DNA
sequences and a coding ratio of 86%. Simultaneously, bioactivity-guided purifcation of the bacterial extract resulted in
six polyketide classes of compounds with promising antibacterial activity. Draft genome sequence of B. amyloliquefaciens
MB6 unveiled biosynthetic gene clusters (BGCs) engaged in the biosynthesis of polyketide–originated macrolactones with
prospective antagonistic activity (MIC≤5 µg/mL) against nosocomial pathogens. Genome analysis manifested 34 putative
BGCs necessitated to synthesize biologically active polyketide-originated frameworks or their derivatives. These results
provide insights into the genetic basis of heterotrophic B. amyloliquefaciens MTCC 12,716 as a prospective lead for biotechnological and pharmaceutical applications
 
Publisher Springer
 
Date 2021
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/15346/1/Marine%20Biotechnology_2021_Kajal%20Chakraborty.pdf
Chakraborty, Kajal and Vinaya, K K and Joy, Minju and Chakraborty, Rekha D (2021) Leap Forward towards Unraveling Newer Anti‑infective Agents from an Unconventional Source: a Draft Genome Sequence Illuminating the Future Promise of Marine Heterotrophic Bacillus sp. Against Drug‑Resistant Pathogens. Marine Biotechnology. pp. 1-19.