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Turbinafuranone A–C, new 2-furanone analogues from marine macroalga Turbinaria ornata as prospective anti-hyperglycemic agents attenuate tyrosine phosphatase-1B

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Relation http://eprints.cmfri.org.in/15289/
https://link.springer.com/article/10.1007%2Fs00044-021-02762-1
 
Title Turbinafuranone A–C, new 2-furanone analogues from marine
macroalga Turbinaria ornata as prospective anti-hyperglycemic
agents attenuate tyrosine phosphatase-1B
 
Creator Dhara, Subhajit
Chakraborty, Kajal
 
Subject Biochemistry
Fish Biotechnology
 
Description Chemical investigation of Phaeophytan marine macroalga Turbinaria ornata (family Sargassaceae) resulted in the
characterization of three 2-furanone analogues, which were characterized as 6, 7-dihydroxy-8-methyl-3-(5′-methyloct-4′-
en-1′-yl)-hexahydrocyclooct-1-en-[1, 2-c]furan-11-one (turbinafuranone A), 4-hydroxy-3-isopropyl-7, 8-dimethyl-6-
(pentan-2′-acetate)-hexahydrocycloocta-1-en-[1, 2-c]furan-11-one (turbinafuranone B), and 6-acetoxy-8-ethyl-5-methoxy�3-(2′-methylhex-4′-en-1′-yl)-pentahydrocycloocta-1, 7-dien-[1, 2-c]furan-11-one (turbinafuranone C). Inhibitory property
of turbinafuranone B against tyrosine phosphatase-1B was significantly greater (IC50 2.42 mM) than standard agent sodium
metavanadate (IC50 2.52 mM). Greater electronic properties along with molecular docking experiments corroborated the
attenuation property of turbinafuranone B against protein tyrosine phosphatase-1B, by exhibiting minimum binding energy
of −11.80 kcal/mol compared to other studied analogues. The results demonstrated that the undescribed turbinafuranone B
might be used as prospective natural anti-hyperglycemic lead to alleviate the likelihood of higher postprandial blood
glucose levels.
 
Publisher Springer
 
Date 2021
 
Type Article
NonPeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/15289/2/Medicinal%20Chemistry%20Research_2021_Chakraborty%20Kajal.pdf
Dhara, Subhajit and Chakraborty, Kajal (2021) Turbinafuranone A–C, new 2-furanone analogues from marine macroalga Turbinaria ornata as prospective anti-hyperglycemic agents attenuate tyrosine phosphatase-1B. Medicinal Chemistry Research, 30. pp. 1635-1648.