Record Details

<p style="text-align: justify;"><em>In vitro</em> antidiabetic activities of Myanmar medicinal plants: <em>Cassia siamea </em>Lam. and <em>Butea monosperma </em>Roxb.</p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p style="text-align: justify;"><em>In vitro</em> antidiabetic activities of Myanmar medicinal plants: <em>Cassia siamea </em>Lam. and <em>Butea monosperma </em>Roxb.</p>
 
Added Entry - Uncontrolled Name Thida, Mya ; Cell Culture Laboratory, Ministry of Science and Technology, Kyaukse 05151, Myanmar
Moe, The Su; Pharmaceutical Research Laboratory, Ministry of Science and Technology, Kyaukse 05151, Myanmar
Chan, Khin Nyein; Cell Culture Laboratory, Ministry of Science and Technology, Kyaukse 05151, Myanmar
Ei, Shun Lai; Cell Culture Laboratory, Ministry of Science and Technology, Kyaukse 05151, Myanmar
Khai, Aye Aye; Biotechnology Research Department, Ministry of Science and Technology, Kyaukse 05151, Myanmar
Department of Research and Innovation, Ministry of Science and Technology, Myanmar
 
Uncontrolled Index Term Cytotoxic activity; Diabetes mellitus; Dipeptidyl peptidase IV (DPP-IV); Glucose uptake; Insulin
 
Summary, etc. <p style="text-align: justify;">This study aimed to evaluate the antidiabetic potentials of <em>Cassia siamea</em> and <em>Butea monosperma</em>. Cytotoxic activity of test extracts was performed by a hemolytic assay. Estimation of the antidiabetic properties was explored by α-glucosidase and DPP-IV inhibition assays. The glucose transportation activity of test extracts across the yeast cells was expressed by a glucose uptake assay<strong>. </strong>Non-hemolytic effects of test extracts were shown as lysis per cent less than 15 on RBCs. The inhibition potential of test extracts on α-glucosidase enzyme illustrates that IC<sub>50</sub> values (μg/mL) of <em>C. siamea </em>was 76.33±12.2 and <em>B. monosperma</em> was 77.28±2.02. While the IC<sub>50</sub> values of the acarbose was 36.76±1.55 μg/mL. In addition, the tested extracts showed the ability to inhibit DPP-IV enzyme activity in a concentration-dependent manner. The IC<sub>50</sub> (μg/mL) values of <em>C. siamea, B. monosperma, </em>and the sitagliptin were 117.02±9.73, 103±8.5, and 144.85±13.43, respectively in DPP-IV inhibitory assay. Moreover, the test extracts could transport glucose in yeast cells representing the glucose uptake effectively especially in <em>B. monosperma</em> with a concentration-dependent manner in all tested glucose concentrations. This study provided that the tested extracts promise to possess the antidiabetic potential with non-hemolytic properties, diabetic-enzymes suppressing potency and glucose utilizing ability.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-12-05 09:59:16
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJNPR/article/view/63881
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 13, ##issue.no## 4 (2022): December 2022 (Ahead of Print)
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/63881/465611567
http://op.niscair.res.in/index.php/IJNPR/article/download/63881/465611568
 
Terms Governing Use and Reproduction Note Authors who publish with IJNPR agree that once published copyright of the article will be transferred to the publisher, with the work simultaneously licensed under a Creative Commons Attribution-BY-NC-ND 4.0 International License.. that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. Except where otherwise noted, the Articles on this site are licensed underCreative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India