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Synthesis, characterization and fungicidal activity of novel 2-aminopyrimidine Schiff bases

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Title Synthesis, characterization and fungicidal activity of novel 2-aminopyrimidine Schiff bases
 
Creator Kaur, Amanpreet
Sharma, Sunita
Verma, Diksha
Sahni, Tanvi
Kaur, Sukhmanpreet
 
Subject 2-aminopyrimidine
Schiff base
Aromatic aldehydes
Conventional and microwave method
Antifungal activity
 
Description 42-48
2-Aminopyrimidines represents vital class of bioactive molecules where its structural changes would lead to its peculiar
properties. N-heterocyclic compound i.e. 2-aminopyrimidine had wide range of applications in pharmacological, material
chemistry and agriculture as antifungal, antimicrobial and antibacterial agents. 2-Aminopyrimidine and its derivatives are
good candidates for antimicrobial, antifungal and anticorrosion activity. In the present study, a series of substituted
N-benzylidine-2-aminopyrimidine compounds have been synthesized by condensation reaction of 2-aminopyrimidine with
substituted benzaldehydes (o-chloro, m-hydroxybenzaldehyde, p-hydroxybenzaldehyde, 2,5-dimethoxybenzaldehyde,
p-dimethylaminobenzaldehye, syringaldehyde, o-phthaldehyde, isovanillin benzaldehyde, veratraldehyde and thiophene-2-
carboxyaldehyde) using glacial acetic acid or NaOH (40%). The synthesised Schiff bases have been characterized using UV,
IR, 1H NMR and 13C spectral studies. 2-Aminopyrimidine Schiff bases (1-10) have been examined for fungitoxicity on the
growth of Fusarium verticillioides, Rhizoctonia solani and Macrophomina phaseolina using poisoned food technique.
 
Date 2023-01-18T10:51:38Z
2023-01-18T10:51:38Z
2023-01
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61216
https://doi.org/10.56042/ijc.v62i1.70390
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.62(01) [Jan 2023]