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Quantifying the transmission of antimicrobial resistance at the human and livestock interface with genomics

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Title Quantifying the transmission of antimicrobial resistance at the human and livestock interface with genomics
 
Creator Wee, B.A.
Muloi, D.M.
Bunnik, B.A.D. van
 
Subject antimicrobial resistance
livestock
health
humans
genomics
 
Description Background Livestock have been implicated as a reservoir for antimicrobial resistance (AMR) that can spread to humans. Close proximity and ecological interfaces involving livestock have been posited as risk factors for the transmission of AMR. In spite of this, there are sparse data and limited agreement on the transmission dynamics that occur. Objectives To identify how genome sequencing approaches can be used to quantify the dynamics of AMR transmission at the human–livestock interface, and where current knowledge can be improved to better understand the impact of transmission on the spread of AMR. Sources Key articles investigating various aspects of AMR transmission at the human–livestock interface are discussed, with a focus on Escherichia coli. Content We recapitulate the current understanding of the transmission of AMR between humans and livestock based on current genomic and epidemiological approaches. We discuss how the use of well-designed, high-resolution genome sequencing studies can improve our understanding of the human–livestock interface. Implications A better understanding of the human–livestock interface will aid in the development of evidence-based and effective One Health interventions that can ultimately reduce the burden of AMR in humans.
 
Date 2020-12
2020-11-12T13:53:39Z
2020-11-12T13:53:39Z
 
Type Journal Article
 
Identifier Wee, B.A., Muloi, D.M. and Bunnik, B.A.D. van. 2020. Quantifying the transmission of antimicrobial resistance at the human and livestock interface with genomics. Clinical Microbiology and Infection 26(12): 1612–1616.
1198-743X
https://hdl.handle.net/10568/110142
https://doi.org/10.1016/j.cmi.2020.09.019
 
Language en
 
Rights CC-BY-4.0
Open Access
 
Format p. 1612-1616
 
Publisher Elsevier
 
Source Clinical Microbiology and Infection