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<p>Synthesis of some new isoxazole-piperidine-1,2,3-triazoles as <em>in vitro </em>anticancer agents</p>

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Title Statement <p>Synthesis of some new isoxazole-piperidine-1,2,3-triazoles as <em>in vitro </em>anticancer agents</p>
 
Added Entry - Uncontrolled Name Peddapyata, Prashanth Raja; Department of Chemistry, Chaitanya (Deemed to be University), Hanamkonda, Telangana 506 001, India
Ega, Jagadeesh Kumar; Department of Chemistry, Chaitanya (Deemed to be University), Hanamkonda, Telangana 506 001, India
Siddoju, Kavitha ; Department of Chemistry, Chaitanya (Deemed to be University), Hanamkonda, Telangana 506 001, India
 
Uncontrolled Index Term Isoindole, 1,2,3-triazole, Anticancer activity
 
Summary, etc. <p style="text-align: justify;">The synthesis of some new isoxazole-piperidine-1,2,3-triazoles (4a-4j) have been achieved using Sharpless Cu(I) catalyzed [3+2] cycloaddition as a key approach.<strong> </strong>The <em>in vitro </em>anticancer screening of all the compounds against four human cancer cell lines including MCF-7, HeLa, A549 and IMR32 has revealed that the compounds <strong>4c</strong> and <strong>4f </strong>exhibited promising activity against all the cell lines as compared to etoposide. Rest of the compounds have shown good to zero activity against specific cell line when compared with the positive control. Predominantly, the compound <strong>4c</strong> is showing superior activity against IMR32 which posses IC<sub>50</sub> value 3.2±0.3 mM.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2023-01-19 15:48:46
 
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http://op.niscair.res.in/index.php/IJC/article/view/70389
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 62, ##issue.no## 1 (2023): Indian Journal of Chemistry-(IJC)
 
Language Note en