Record Details

<p>Investigation of 2-oxopyrrolidine 5-carboxylic acid amides derivatives as potential anti-tubercular agents based on the similarity screening results from molecular fingerprints and swiss similarity</p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p>Investigation of 2-oxopyrrolidine 5-carboxylic acid amides derivatives as potential anti-tubercular agents based on the similarity screening results from molecular fingerprints and swiss similarity</p>
 
Added Entry - Uncontrolled Name Nagasree, K P; Pharmaceutical Chemistry Research Lab, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam – 530 003, India
Umarani, W A; Pharmaceutical Chemistry Research Lab, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam – 530 003, India
K, K P Sony; Pharmaceutical Chemistry Research Lab, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam – 530 003, India
Kumar, K S; Pharmaceutical Chemistry Research Lab, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam – 530 003, India
Kumar, M Murali Krishna; Pharmaceutical Chemistry Research Lab, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam – 530 003, India
 
Uncontrolled Index Term Pyroglutamic acid, 2-oxopyrrolidine 5-carboxylic acid amides derivatives, anti-tubercular activity, CHEMDES, SWISS SIMILARITY
 
Summary, etc. <p style="text-align: justify;">Many open source <em>in silico</em> tools are available for drug discovery, this paper attempts to correlate the results obtained from two such tools with results obtained from <em>in vitro</em> screening. Discovery of novel Anti-TB agents became a necessity due to the ever increasing problem of drug resistance. As heterocyclic compounds are known to possess potent biological activity, here an attempt has been made to synthesize pyrazolidine derivatives from pyroglutamic acid. Further the synthesized derivatives are analyzed by IR, NMR and Mass spectral studies and screened for anti-tubercular and antimicrobial activity.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2023-01-19 15:48:46
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/70391
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 62, ##issue.no## 1 (2023): Indian Journal of Chemistry-(IJC)
 
Language Note en