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The genome landscape of indigenous African cattle

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Title The genome landscape of indigenous African cattle
 
Creator Kim, Jaemin
Hanotte, Olivier H.
Okeyo Mwai, Ally
Dessie, Tadelle
Salim, Bashir
Diallo, Boubacar
Agaba, Morris
Kwondo Kim
Woori Kwak
Samsun Sung
Seo, Minseok
Jeong, Hyeonsoo
Kwon, Taehyung
Taye, Mengistie
Song, Ki-Duk
Lim, Dajeong
Seoae Cho
Lee, Hyun-Jeong
Duhak Yoon
Sung Jong Oh
Kemp, Stephen J.
Hak-Kyo Lee
Heebal Kim
 
Subject indigenous breeds
breeds
animal breeding
livestock
cattle
genomes
adaptation
 
Description Background: The history of African indigenous cattle and their adaptation to environmental and human selection pressure is at the root of their remarkable diversity. Characterization of this diversity is an essential step towards understanding the genomic basis of productivity and adaptation to survival under African farming systems. Results: We analyze patterns of African cattle genetic variation by sequencing 48 genomes from five indigenous populations and comparing them to the genomes of 53 commercial taurine breeds. We find the highest genetic diversity among African zebu and sanga cattle. Our search for genomic regions under selection reveals signatures of selection for environmental adaptive traits. In particular, we identify signatures of selection including genes and/ or pathways controlling anemia and feeding behavior in the trypanotolerant N’Dama, coat color and horn development in Ankole, and heat tolerance and tick resistance across African cattle especially in zebu breeds. Conclusions: Our findings unravel at the genome-wide level, the unique adaptive diversity of African cattle while emphasizing the opportunities for sustainable improvement of livestock productivity on the continent.
 
Date 2017-12
2017-02-23T09:29:45Z
2017-02-23T09:29:45Z
 
Type Journal Article
 
Identifier Kim, J., Hanotte, O., Mwai, O.A., Dessie, T., Bashir, S., Diallo, B., Agaba, M., Kim, K., Kwak, W., Sung, S., Seo, M., Jeong, H., Kwon, T., Taye, M., Ki-Duk Song, Dajeong Lim, Seoae Cho, Hyun-Jeong Lee, Duhak Yoon, Sung Jong Oh, Kemp, S., Hak-Kyo Lee and Heebal Kim. 2017. The genome landscape of indigenous African cattle. Genome Biology 18:34
1474-760X
https://hdl.handle.net/10568/80008
https://doi.org/10.1186/s13059-017-1153-y
 
Language en
 
Rights Copyrighted; all rights reserved
Open Access
 
Publisher Springer Science and Business Media LLC
 
Source Genome Biology