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African swine fever virus (ASFV): Biology, genomics and genotypes circulating in sub-Saharan Africa

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Title African swine fever virus (ASFV): Biology, genomics and genotypes circulating in sub-Saharan Africa
 
Creator Njau, Emma P.
Machuka, Eunice M.
Cleaveland, S.
Shirima, G.M.
Kusiluka, L.J.
Okoth, Edward A.
Pelle, Roger
 
Subject african swine fever virus
swine
genomics
virology
infectious diseases
 
Description African swine fever (ASF) is a highly infectious and fatal haemorrhagic disease of pigs that is caused by a complex DNA virus of the genus Asfivirus and Asfarviridae African suids family. The disease is among the most devastating pig diseases worldwide including Africa. Although the disease was first reported in the 19th century, it has continued to spread in Africa and other parts of the world. Globally, the rising demand for pork and concomitant increase in transboundary movements of pigs and pork products is likely to increase the risk of transmission and spread of ASF and pose a major challenge to the pig industry. Different genotypes of the ASF virus (ASFV) with varying virulence have been associated with different outbreaks in several countries in sub-Saharan Africa (SSA) and worldwide, and understanding genotype circulation will be important for ASF prevention and control strategies. ASFV genotypes unique to Africa have also been reported in SSA. This review briefly recounts the biology, genomics and genotyping of ASFV and provides an account of the different genotypes circulating in SSA. The review also highlights prevention, control and progress on vaccine development and identifies gaps in knowledge of ASFV genotype circulation in SSA that need to be addressed.
 
Date 2021-11-15
2021-11-30T16:14:55Z
2021-11-30T16:14:55Z
 
Type Journal Article
 
Identifier Njau, E.P., Machuka, E.M., Cleaveland, S., Shirima, G.M., Kusiluka, L.J., Okoth, E.A. and Pelle, R. 2021. African swine fever virus (ASFV): Biology, genomics and genotypes circulating in sub-Saharan Africa. Viruses 13(11): 2285.
1999-4915
https://hdl.handle.net/10568/116402
https://doi.org/10.3390/v13112285
 
Language en
 
Rights CC-BY-4.0
Open Access
 
Format 2285
 
Publisher MDPI
 
Source Viruses