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Polymorphisms in MC1R and ASIP Genes are associated with Coat Color Variation in the Arabian Camel

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Title Polymorphisms in MC1R and ASIP Genes are associated with Coat Color Variation in the Arabian Camel
 
Creator Almathen, Faisal
Elbir, Haitham
Bahbahani, Hussain
Mwacharo, Joram M.
Hanotte, Olivier H.
 
Subject camels
animal breeding
livestock
 
Description Pigmentation in mammals is primarily determined by the distribution of eumelanin and pheomelanin, the ratio of which is mostly controlled by the activity of melanocortin 1 receptor (MC1R) and agouti signaling protein (ASIP) genes. Using 91 animals from 10 Arabian camel populations, that included the 4 predominant coat color phenotypes observed in the dromedary (light brown, dark brown, black, and white), we investigated the effects of the MC1R and ASIP sequence variants and identified candidate polymorphisms associated with coat color variation. In particular, we identified a single nucleotide polymorphism (SNP), found in the coding region of MC1R (901C/T), linked to the white coat color, whereas a 1-bp deletion (23delT/T) and a SNP (25G/A) in exon 2 of ASIP are associated with both black and dark-brown coat colors. Our results also indicate support that the light-brown coat color is likely the ancestral coat color for the dromedary. These sequence variations at the MC1R and ASIP genes represent the first documented evidence of candidate polymorphisms associated with Mendelian traits in the dromedary.
 
Date 2018-08-24
2018-08-31T05:56:38Z
2018-08-31T05:56:38Z
 
Type Journal Article
 
Identifier Almathen, F., Elbir, H., Bahbahani, H., Mwacharo, J. and Hanotte, O. 2018. Polymorphisms in MC1R and ASIP Genes are associated with Coat Color Variation in the Arabian Camel. Journal of Heredity 109(6):700–706.
1465-7333
https://hdl.handle.net/10568/97018
https://doi.org/10.1093/jhered/esy024
 
Language en
 
Rights CC-BY-4.0
Open Access
 
Format p. 700-706
 
Source Journal of Heredity