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Risk factors for the delayed viral clearance in COVID-19 patients

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Title Risk factors for the delayed viral clearance in COVID-19 patients
 
Creator Chen, X.
Hu, W.
Yang, M.
Ling, J.
Zhang, Y.
Deng, L.
Li, J.
Lundkvist, Å.
Lindahl, Johanna F.
Xiong, Y.
 
Subject covid-19
health
hypertension
 
Description Comorbidities are important for the disease outcome of COVID-19, however, which underlying diseases that contribute the most to aggravate the conditions of COVID-19 patients are still unclear. Viral clearance is the most important laboratory test for defining the recovery of COVID-19 infections. To better understand which underlying diseases that are risk factors for delaying the viral clearance, we retrospectively analyzed 161 COVID-19 clinical cases in the Zhongnan Hospital of Wuhan University, Wuhan, China between January 5 and March 13, 2020. The demographic, clinical and laboratory data, as well as patient treatment records were collected. Univariable and multivariable analysis were performed to explore the association between delayed viral clearance and other factors by using logistic regression. Survival analyses by Kaplan-Meier and Cox regression modeling were employed to identify factors negatively influencing the viral clearance negatively. We found that hypertension and intravenous immunoglobulin adversely affected the time of viral RNA shedding. Hypertension was the most important risk factor to delay the SARS-CoV-2 virus clearance, however, the use of Angiotensin-Converting Enzyme Inhibitors(ACEI)/Angiotensin Receptor Blockers(ARB) did not shorten the time for virus clearance in these hypertensive patients' virus clearance. We conclude that patients having hypertension and intravenous immunoglobulin may delay the viral clearance in COVID-19 patients.
 
Date 2021-08
2021-06-28T07:36:50Z
2021-06-28T07:36:50Z
 
Type Journal Article
 
Identifier Chen, X., Hu, W., Yang, M., Ling, J., Zhang, Y., Deng, L., Li, J., Lundkvist, Å., Lindahl, J.F. and Xiong, Y. 2021. Risk factors for the delayed viral clearance in COVID-19 patients. Journal of Clinical Hypertension 23(8): 1483–1489.
1524-6175
https://hdl.handle.net/10568/114129
https://doi.org/10.1111/jch.14308
 
Language en
 
Rights CC-BY-NC-ND-4.0
Open Access
 
Format p. 1483-1489
 
Publisher Wiley
 
Source Journal of Clinical Hypertension