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Passive surveillance of human African trypanosomiasis in Côte d'Ivoire: Understanding prevalence, clinical symptoms and signs, and diagnostic test characteristics

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Title Passive surveillance of human African trypanosomiasis in Côte d'Ivoire: Understanding prevalence, clinical symptoms and signs, and diagnostic test characteristics
 
Creator Koné, M.
Kaba, D.
Kaboré, J.
Thomas, Lian F.
Falzon, Laura C.
Koffi, M.
Kouamé, C.M.
Ahouty, B.
Compaoré, C.
N'Gouan, E.K.
Solano, P.
Fèvre, Eric M.
Büscher, P.
Lejon, V.
Jamonneau, V.
 
Subject african trypanosomiasis
disease surveillance
diagnosis
health
 
Description Background: Little is known about the diagnostic performance of rapid diagnostic tests (RDTs) for passive screening of human African trypanosomiasis (HAT) in Côte d'Ivoire. We determined HAT prevalence among clinical suspects, identified clinical symptoms and signs associated with HAT RDT positivity, and assessed the diagnostic tests' specificity, positive predictive value and agreement. Methods: Clinical suspects were screened with SD Bioline HAT, HAT Sero-K-Set and rHAT Sero-Strip. Seropositives were parasitologically examined, and their dried blood spots tested in trypanolysis, ELISA/Tbg, m18S-qPCR and LAMP. The HAT prevalence in the study population was calculated based on RDT positivity followed by parasitological confirmation. The association between clinical symptoms and signs and RDT positivity was determined using multivariable logistic regression. The tests' Positive Predictive Value (PPV), specificity and agreement were determined. Results: Over 29 months, 3433 clinical suspects were tested. The RDT positivity rate was 2.83%, HAT prevalence 0.06%. Individuals with sleep disturbances (p
 
Date 2021-08-30
2021-09-01T06:42:44Z
2021-09-01T06:42:44Z
 
Type Journal Article
 
Identifier Koné, M., Kaba, D., Kaboré, J., Thomas, L.F., Falzon, L.C., Koffi, M., Kouamé, C.M., Ahouty, B., Compaoré, C., N'Gouan, E.K., Solano, P., Fèvre, E., Büscher, P., Lejon, V. and Jamonneau, V. 2021. Passive surveillance of human African trypanosomiasis in Côte d'Ivoire: Understanding prevalence, clinical symptoms and signs, and diagnostic test characteristics. PLOS Neglected Tropical Diseases 15(8): e0009656.
1935-2735
https://hdl.handle.net/10568/114841
https://doi.org/10.1371/journal.pntd.0009656
 
Language en
 
Rights CC-BY-4.0
Open Access
 
Format e0009656
 
Source PLOS Neglected Tropical Diseases