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Molecular docking and cytotoxicity interactions of naringenin and its na o-structured lipid carriers in ERα positive breast cancer

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Title Molecular docking and cytotoxicity interactions of naringenin and its na o-structured lipid carriers in ERα positive breast cancer
 
Creator S, Priyadharshini
Swaroop, Akey Krishna
S, Jubie
N, Jawahar
Divecha, Vrajesh
 
Subject Angiogenesis
Cytotoxicity
Ligand
Mannitol
Metastasis
Phytoestrogens
Surfactant
 
Description 141-147
Phytoestrogens are known to have beneficial properties in various carcinomas. They exhibit its efficacy at cellular levels. Naringenin a flavonoidal phytoestrogen is been explored for its antioxidant, cardio protective and cytotoxic function. The low absorbtion and poor bioavailability of naringenin makes it less efficient in targeting tumours at cellular levels. Due to the structural similarity of naringenin with estradiol and considering the affinity of naringenin with estrogen receptor, this study explores the interactions of naringenin on important signaling proteins involved in ER positive breast cancer through molecular docking studies and the prepared naringenin solid lipid nano particles were characterized and studied for its preventive potential against breast cancer cell lines. The lipidoid form of phytoestrogen shows promising cytotoxic potential compared with naringenin.
 
Date 2023-01-25T06:41:47Z
2023-01-25T06:41:47Z
2023-01
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/61250
https://doi.org/10.56042/ijbb.v60i2.70688
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.60(02) [February 2023]