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Formulation and evaluation of Buccal mucoadhesive tablets of diclofenac sodium using 23 factorial designs

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Title Formulation and evaluation of Buccal mucoadhesive tablets of diclofenac sodium using 23 factorial designs
 
Creator Singh, Madhu Tanya
Shekhar, Nunavath Raja
Yerrakula, Goutham
Venkatachalam, Senthil
 
Subject Buccal tablets
Diclofenac sodium
Drug release
Mucoadhesion
Mucoadhesive tablets
Release kinetics
 
Description 122-128
Diclofenac sodium is an NSAID (Non-Steroidal anti-inflammatory widely used in the treatment of pain, migraine, and
inflammation). It has been observed that Diclofenac undergoes extensive first-pass metabolism when administered using
conventional dosage forms through the oral route. The aim of this study is to formulate and evaluate pre-compression, postcompression
factors and release kinetics of buccal mucoadhesive tablets formulated by a 23 factorial method that can
prevent the first-pass metabolism of the drug thereby increasing its bioavailability. This formulation increases patient
compliance by reducing its dosing frequency. In these formulations, two polymers polyvinyl pyrrolidine (PVP K30) and
Chitosan are used in varying proportions. Eight different formulations were prepared by varying concentrations of the
polymers. The buccal mucoadhesive tablets formulated have been evaluated for their general appearance, thickness,
hardness, weight variation, friability and other in vitro tests such as swelling and dissolution studies. The evaluation studies
demonstrated that formulation F8 showed better properties as a buccal mucoadhesive formulation compared to other
formulations.
 
Date 2023-01-25T06:48:32Z
2023-01-25T06:48:32Z
2023-01
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/61254
https://doi.org/10.56042/ijbb.v60i2.70742
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.60(02) [February 2023]