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Identification of phytoconstituents for combating Polycystic ovarian syndrome through in silico techniques

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Title Identification of phytoconstituents for combating Polycystic ovarian syndrome through in silico techniques
 
Creator L, Pavithra
Ilango, K
 
Subject Ficus religiosa
In silico studies
Lanosterol
Polycystic ovarian syndrome
Sesamin
Sesamum indicum
 
Description 99-107
Polycystic ovarian syndrome is one of the leading causes for infertility in women. One in Five women of the population
is affected by PCOS. The synthetic drugs currently used are targeted to provide an artificial support for the hormonal
imbalance in the body which leads to various adverse effects. Natural herbs serve as a best remedy for many of the diseases
as they cure the root cause and target the disease specifically. Selection of herbs is a crucial part in the formulation. In silico
studies play an important role in analyzing the activity of the compound with the selected target. The herbs which had
reported biological activity on uterus were selected and their vital chemical constituents were docked with the identified
target of PDB ID 3RUK and 1E3K, respectively. The values obtained shows the potential effect of chemical constituent with
the suitable target. Among the list of herbs selected, Sesamin from Sesamum indicum and lanosterol from Ficus religiosa
had good binding affinity with both the selected proteins and had better drug likeliness properties. Hence, further studies on
these compounds for targeting PCOS is expected to give potent activity and produce promising results.
 
Date 2023-01-25T06:56:36Z
2023-01-25T06:56:36Z
2023-01
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/61257
https://doi.org/10.56042/ijbb.v60i2.70682
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.60(02) [February 2023]