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‘TRAIL’ of targeted colorectal cancer therapy

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Title ‘TRAIL’ of targeted colorectal cancer therapy
 
Creator Jain, Nishakumari
Roychowdhury, Parikshit
Bhuyan, Nihar Ranjan
Kuppusamy, Gowthamarajan
 
Subject Adenosquamous
Apoptosis
Capsazepine
Carcinoma
Doxorubicin
Necrosis
Protein kinase
 
Description 95-98
TRAIL, a tumor necrosis factor-related apoptosis-inducing ligand is a member of the tumor necrosis factor (TNF)
superfamily, which is a cytokine that has shown a particularly precise and selective affinity towards death receptors that are
overexpressed in cancer cells. While leaving the normal cells intact and unharmed, due to this property it has been the ligand
of choice for highly precise cancer chemotherapeutic delivery system development. On numerous occasions, TRAIL has
been used singularly and in combination with other drugs. It was observed that TRAIL had a tendency to be susceptible in
terms of the cancer cells developing resistance against it. So TRAIL monotherapy was a bit of a rough patch for the
molecule to become successful in the chemotherapy universe, however the conjugations and synergistic actions of TRAIL
opened up new horizons which are discussed in this review with specific interest on colorectal cancer (CRC).
 
Date 2023-01-25T07:00:36Z
2023-01-25T07:00:36Z
2023-01
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/61258
https://doi.org/10.56042/ijbb.v60i2.70737
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.60(02) [February 2023]