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Sulfated polygalactofucan from triangular sea bell Turbinaria decurrens attenuates inflammatory cytokines on THP-1 human monocytic macrophages

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Relation http://eprints.cmfri.org.in/16645/
https://www.sciencedirect.com/science/article/pii/S014181302300096X?via%3Dihub
https://doi.org/10.1016/j.ijbiomac.2023.123220
 
Title Sulfated polygalactofucan from triangular sea bell Turbinaria decurrens attenuates inflammatory cytokines on THP-1 human monocytic macrophages
 
Creator Chakraborty, Kajal
Thambi, Anjaly
Dhara, Subhajit
 
Subject Algal nutrition
Bioactive compounds
Biochemistry
Algae
 
Description Inflammation is one of the most significant causes of several chronic diseases, which includes the expression of cytokines activating immune cells to up-regulate the inflammatory cascade. Polysaccharides from marine macroalgae are promising anti-inflammatory agents because of their potential to attenuate inflammatory cytokines. The triangular sea bell Turbinaria decurrens (Sargassaceae) among marine macroalgae is ubiquitous in oceanic waters, and a sulfated polygalactofucan SPTd-2 [→3-(α-L-fucp-(2-OSO3−)-(1 → 4)-α-L-fucp-(3-OAc)-(1 → 4)-β-D-galp-(1→] was purified from the species. The studied polygalactofucan SPTd-2 exhibited anti-inflammatory activities against cyclooxygenase-2 (IC50 10.56 μM) and 5-lipoxygenase (IC50 3.36 μM) with a greater selectivity index (2.35) than ibuprofen (0.44), besides attenuating pro-inflammatory cytokine production, including tumor necrosis factor-α, transforming growth factor-β, interleukin-2, 1β, and interferon-γ. Quantitative real-time polymerase chain reaction displayed that SPTd-2 blocked the mRNA of interferon-γ and interleukin-2, in the human monocytic cell line THP-1. The results showed the potential of SPTd-2 to attenuate inflammation-associated disorders.
 
Publisher Elsevier
 
Date 2023
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/16645/1/International%20Journal%20of%20Biological%20Macromolecules_2023_Kajal%20Chakraborty.pdf
Chakraborty, Kajal and Thambi, Anjaly and Dhara, Subhajit (2023) Sulfated polygalactofucan from triangular sea bell Turbinaria decurrens attenuates inflammatory cytokines on THP-1 human monocytic macrophages. International Journal of Biological Macromolecules, 231. pp. 1-10. ISSN 1879-0003