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Characterisation and microbial activity of neem oil nano-emulsions formulated by phase inversion temperature method

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Title Characterisation and microbial activity of neem oil nano-emulsions formulated by phase inversion temperature method
 
Creator Safaya, M
Nandwani, S
Rotliwala, Y C
 
Subject Antibacterial
Droplet size
Neem oil
Non-ionic surfactant
Phase inversion temperature
Ternary phase diagram
 
Description 137-142
This study has been carried out to prepare neem oil-in-water nano-emulsions stabilized by Brij 30 surfactant using the
phase inversion temperature (PIT) method at three different temperatures, i.e., 60, 75 and 80°C. Compositions of
homogenous phase have been identified in the pseudo-ternary phase diagram. Among the total seventeen formulations, three
formulations (NB1, NB2 and NB3) have been short-listed and characterized for emulsion size and viscosity. The selected
formulations have shown emulsion size of 348-981 nm in diameter. The volume percentage ratio of Brij 30 to neem oil have
shown significant effect on the droplet size of nano-emulsions. Formulations having lower concentration of Brij 30 have
displayed a smaller emulsion droplet size (348 nm). The NB3 formulation (4% neem oil, 11% Brij 30 and 85% deionized
water) has exhibited the highest stability after 60 days of storage. Antimicrobial study has shown that in contrast to raw
neem and Ampicillin (synthetic drug), NB1 exhibited best result in terms of minimum inhibition concentration (MIC)
reduction by 100% against E-coli, P. aeruginosa, S. aureus and S. pyogenus.
 
Date 2023-01-27T06:25:22Z
2023-01-27T06:25:22Z
2023-01
 
Type Article
 
Identifier 0975-0991 (Online); 0971-457X (Print)
http://nopr.niscpr.res.in/handle/123456789/61288
https://doi.org/10.56042/ijct.v30i1.61853
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJCT Vol.30(1) [January 2023]