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Bioprospecting of pods of Moringa oleifera Lam. as novel antibacterial agent

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Title Bioprospecting of pods of Moringa oleifera Lam. as novel antibacterial agent
 
Creator Mukherjee, Devaleena
Chandra, Goutam
 
Subject Antibacterial activity
Ben oil tree
Drumstick tree
Horseradish tree
 
Description 131-137
In the treatment of bacterial diseases, increasing resistance to traditional chemotherapeutics has drawn the necessity for
substitute remedies. In this context, here, we evaluated the bactericidal activity of pods of Moringa oleifera Lam., an ethno
medicinal plant, against eight pathogenic bacterial strains, both Gram positive (Bacillus licheniformis, B. mycoides,
B. subtilis and Staphylococcus aureus) and Gram negative (Escherichia coli, Pseudomonas aeruginosa, P. fluorescens and
P. putida). Different organic solvent extracts, like ethyl acetate, acetone and alcohol, of pods of M. oleifera were examined
for bactericidal activity against test microorganisms. Minimum inhibitory concentration, chromatographic analyses along
with infrared spectroscopy, gas chromatography-mass spectroscopy and nuclear magnetic resonance spectroscopy was
carried out for chemical characterization of active ingredient responsible for antibacterial activity. Both the Gram positive
and Gram negative organisms showed variable sensitivity to different solvent extracts of M. oleifera pods. Ethyl acetate
extracts showed maximum antibacterial activity with MIC value ranging from 1.30 to 4.10 mg/mL. IR analysis provided
preliminary information about the amines, amides, aromatics and sulphur containing compounds of the active ingredient.
GC-MS and NMR analyses indicated the presence of principal bioactive antibacterial compound 2-(benzoylsulfanyl)-1,3-
thiazol,4-yl, benzoate with molecular formula C17H11NO3S2 from ethyl acetate extract of M. oleifera pods. The study
concludes that the compound 2-(benzoylsulfanyl)-1,3-thiazol,4-yl, benzoate from ethyl acetate extract of pods of M. oleifera
possess the antibacterial activity against the tested strains.
 
Date 2023-01-31T10:12:38Z
2023-01-31T10:12:38Z
2023-01
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/61305
https://doi.org/10.56042/ijeb.v61i02.51153
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(02) [Feb 2023]