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Evaluation of subacute toxicity of a polyherbal nootropic formulation in Wistar albino rats

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Title Evaluation of subacute toxicity of a polyherbal nootropic formulation in Wistar albino rats
 
Creator M, Jervin Mano
Lahon, Kingshuk
Gonepannavar, Mangala
Salwe, Kartik J
 
Subject Ayurvedic
Cognitive
Herbal
Traditional medicine
 
Description 116-123
In ayurvedic system of traditional medicine, 'medhyarasayanas' — decoction of selected plants are used to improve
intellect or cognition abilities. Here, we investigated one such polyherbal formulation (PHF) with ingredients Bacopa
monniera, Glycyrrhiza glabra, Valeriana wallechii and Withania somnifera used as a facilitator of learning, retention and
recall. We evaluated the safety of this PHF in animal models. We performed acute oral toxicity test using 2000 mg/kg of the
formulation as per OECD guideline 423 and observed for toxicity over 14 days. Thereafter, we divided them into four
groups of six animals each and administered Normal saline 5 mL/kg, The PHF (Wilmer®) @500, 1000 and 2000 mg/kg in
the respective groups over 28 days. We observed no mortality or physical and behavioural abnormalities in both acute and
subacute toxicity study. On the 28th day, animals were sacrificed, blood collected for estimation of haematological and
biochemical parameters and histopathological examination of organs was performed. There was significant difference (P
 
Date 2023-01-31T10:17:23Z
2023-01-31T10:17:23Z
2023-01
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/61307
https://doi.org/10.56042/ijeb.v61i02.51528
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(02) [Feb 2023]