Record Details

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

CGSpace

View Archive Info
 
 
Field Value
 
Title Maternal nutrition at conception modulates DNA methylation of human metastable epialleles
 
Creator Domínguez Salas, Paula
Moore, S.E.
Baker, M.S.
Bergen, A.W.
Cox, S.E.
Dyer, R.A.
Fulford, A.J.
Guan, Y.
Laritsky, E.
Silver, M.J.
Swan, G.E.
Zeisel, S.H.
Innis, S.M.
Waterland, R.A.
Prentice, A.M.
Hennig, B.J.
 
Subject genetics
 
Description In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet of rural Gambian women allowed us to test this in humans. We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. The level of several of these maternal biomarkers predicts increased/decreased methylation at metastable epialleles in DNA extracted from lymphocytes and hair follicles in infants postnatally. Our results demonstrate that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes at human metastable epialleles.
 
Date 2014-04-29
2014-12-17T07:18:05Z
2014-12-17T07:18:05Z
 
Type Journal Article
 
Identifier Dominguez-Salas, P., Moore, S.E., Baker, M.S., Bergen, A.W., Cox, S.E., Dyer, R.A., Fulford, A.J., Guan, Y., Laritsky, E., Silver, M.J., Swan, G.E., Zeisel, S.H., Innis, S.M., Waterland, R.A., Prentice, A.M. and Hennig, B.J. 2014. Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nature Communications 5: 3746.
2041-1723
https://hdl.handle.net/10568/52239
https://doi.org/10.1038/ncomms4746
 
Language en
 
Rights CC-BY-3.0
Open Access
 
Source Nature Communications