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Anti-diabetic potential of fruit extracts of Flacourtia indica (Burm. F.) Merr-An in-vitro study

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Title Anti-diabetic potential of fruit extracts of Flacourtia indica (Burm. F.) Merr-An in-vitro study
 
Creator Makuttan, Sudhina
Fernandes, Jennifer
G, Ambily P
 
Subject Acarbose
Alpha-amylase
Alpha-glucosidase
Anti-diabetic
Flacourtia indica
 
Description 491-496
Diabetes mellitus is one of the biggest global health problems requiring preventive and new therapeutic interventions.
There is a need for safe, reliable, and cost-effective anti-diabetic drugs, and investigating medicinal plants for new antidiabetic
medications is an exciting research field. Thus, the present study examined the in-vitro anti-diabetic activity of
ethanolic and aqueous extracts of Flacourtia indica (Burm. F.) Merr (Flacourtiaceae) fruits by different enzyme inhibition
assay methods. Alpha-amylase and Alpha-glucosidase are the principal enzymes present in the human body which helps in
the digestion of carbohydrates. Inhibition of these enzymes slows down the absorption of glucose and lowers the sugar level
in the blood. Both extracts showed potent inhibitory activity against these enzymes in a dose-dependent manner. The highest
percentage of inhibition is exhibited by ethanolic extract at a concentration of 100 μg/mL with an IC50 value of 84.02. The
results were compared with the standard drug Acarbose, a competitive inhibitor of both enzymes. The ethanolic extract was
subjected to preliminary phytochemical analysis to find out different chemical constituents. It revealed the presence of
reducing sugars, flavonoids, phenolic compounds, terpenoids, fatty acids, and steroids. Therefore, the current study proved
that both ethanolic and aqueous extracts of F. indica fruits possess bioactive constituents that could be responsible for the
anti-diabetic activity.
 
Date 2023-02-01T09:43:49Z
2023-02-01T09:43:49Z
2023-02
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/61323
https://doi.org/10.56042/ijnpr.v13i4.48344
 
Language en
 
Relation A61K 36/00
A61K 131/00
A61P 3/10
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(4) [December 2022]