Record Details

In vitro antidiabetic activities of Myanmar medicinal plants: Cassia siamea Lam. and Butea monosperma Roxb.

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title In vitro antidiabetic activities of Myanmar medicinal plants: Cassia siamea Lam. and Butea monosperma Roxb.
 
Creator Thida, Mya
Moe, The Su
Chan, Khin Nyein
Ei, Shun Lai
Khai, Aye Aye
 
Subject Cytotoxic activity
Diabetes mellitus
Dipeptidyl peptidase IV (DPP-IV)
Glucose uptake
Insulin
 
Description 483-490
This study aimed to evaluate the antidiabetic potentials of Cassia siamea and Butea monosperma. Cytotoxic activity of
test extracts was performed by a hemolytic assay. Estimation of the antidiabetic properties was explored by α-glucosidase
and DPP-IV inhibition assays. The glucose transportation activity of test extracts across the yeast cells was expressed by a
glucose uptake assay. Non-hemolytic effects of test extracts were shown as lysis per cent less than 15 on RBCs. The
inhibition potential of test extracts on α-glucosidase enzyme illustrates that IC50 values (μg/mL) of C. siamea was
76.33±12.2 and B. monosperma was 77.28±2.02. While the IC50 values of the acarbose was 36.76±1.55 μg/mL. In addition,
the tested extracts showed the ability to inhibit DPP-IV enzyme activity in a concentration-dependent manner. The IC50
(μg/mL) values of C. siamea, B. monosperma, and the sitagliptin were 117.02±9.73, 103±8.5, and 144.85±13.43,
respectively in DPP-IV inhibitory assay. Moreover, the test extracts could transport glucose in yeast cells representing the
glucose uptake effectively especially in B. monosperma with a concentration-dependent manner in all tested glucose
concentrations. This study provided that the tested extracts promise to possess the antidiabetic potential with non-hemolytic
properties, diabetic-enzymes suppressing potency and glucose utilizing ability.
 
Date 2023-02-01T09:50:32Z
2023-02-01T09:50:32Z
2023-02
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/61324
https://doi.org/10.56042/ijnpr.v13i4.63881
 
Language en
 
Relation A61K 36/00
A61P 3/00
A61P 3/10
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(4) [December 2022]