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Plant products as an alternative phytotherapeutics to regulate thrombosis – A review

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Title Plant products as an alternative phytotherapeutics to regulate thrombosis – A review
 
Creator Aggarwal, Sawetaji and Kamal Krishan
 
Subject Alternative therapeutics
Anticoagulant
Plant products
Thrombin
Thrombosis
 
Description 460-467
Thrombosis, a life-threatening disease causes thrombus formation within blood vessels to obstruct the flow of blood
through vascular system. The disease causes morbidity and mortality of arterial and venous thrombosis which can result in
acute infraction and deep vein thrombosis. Majority of clotting factors are serine proteases and are present as precursors of
proteolytic enzymes known as zymogens that circulate in inactivated forms but get activated in response to injury in blood
vessels. The serine proteases are involved in coagulation, anticoagulation, and fibrinolysis. Thrombin and fibrin are the main
key therapeutic target for the treatment of thrombosis. Commercially available antithrombotic and thrombolytic drugs are
known to be associated with serious side effects like bleeding, hypertension, and haemorrhage therefore natural products
have been suggested as best replacement of synthetic antithrombotic and thrombolytic drugs with less side effects for human
health. Plants have been suggested as potential source of anticoagulants against thrombosis with fewer or no side effects.
 
Date 2023-02-01T10:01:46Z
2023-02-01T10:01:46Z
2023-02
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/61327
https://doi.org/10.56042/ijnpr.v13i4.54923
 
Language en
 
Relation A61K 36/00
A61P 7/00
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(4) [December 2022]