Synthesis, characterization and fungicidal activity of novel 2-aminopyrimidine Schiff bases
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Title |
Synthesis, characterization and fungicidal activity of novel 2-aminopyrimidine Schiff bases
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Creator |
Kaura, Amanpreet
Sharmab, Sunita Verma, Diksha Sahni, Tanvi Kaur, Sukhmanpreet |
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Subject |
2-aminopyrimidine
Schiff base Aromatic aldehydes Conventional and microwave method Antifungal activity |
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Description |
42-48
2-Aminopyrimidines represents vital class of bioactive molecules where its structural changes would lead to its peculiar properties. N-heterocyclic compound i.e. 2-aminopyrimidine had wide range of applications in pharmacological, material chemistry and agriculture as antifungal, antimicrobial and antibacterial agents. 2-Aminopyrimidine and its derivatives are good candidates for antimicrobial, antifungal and anticorrosion activity. In the present study, a series of substituted N-benzylidine-2-aminopyrimidine compounds have been synthesized by condensation reaction of 2-aminopyrimidine with substituted benzaldehydes (o-chloro, m-hydroxybenzaldehyde, p-hydroxybenzaldehyde, 2,5-dimethoxybenzaldehyde, p-dimethylaminobenzaldehye, syringaldehyde, o-phthaldehyde, isovanillin benzaldehyde, veratraldehyde and thiophene-2- carboxyaldehyde) using glacial acetic acid or NaOH (40%). The synthesised Schiff bases have been characterized using UV, IR, 1H NMR and 13C spectral studies. 2-Aminopyrimidine Schiff bases (1-10) have been examined for fungitoxicity on the growth of Fusarium verticillioides, Rhizoctonia solani and Macrophomina phaseolina using poisoned food technique. |
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Date |
2023-02-09T10:51:35Z
2023-02-09T10:51:35Z 2023-01 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61377 https://doi.org/10.56042/ijc.v62i1.70390 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJC Vol.62(01) [Jan 2023]
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