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Novel coronavirus vulnerability: Metabolic derangements and altered dehydrogenase enzyme activities are central to the virus pathogenesis in human, bat and other animals

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Title Novel coronavirus vulnerability: Metabolic derangements and altered dehydrogenase enzyme activities are central to the virus pathogenesis in human, bat and other animals
Not Available
 
Creator Sanjib Kumar Manna
 
Subject Covid -19, Vulnerability, Species, Age, Sex, Comorbidity
 
Description Not Available
The ongoing pandemic of novel coronavirus disease (COVID-19) has killed millions across the globe. This paper hypothesizes anaerobic glycolysis and dehydrogenase enzymes as the focal points of SARS-CoV-2 pathogenesis that ensure virus survival and replication in humans and the reservoir host bat. Metabolic alterations in hypertension, diabetes, obesity, and higher reliance on anaerobic glycolysis for energy generation make males and aged people more vulnerable to the disease. The bat has a low level of vitamin D, greater metabolic dependence on anaerobic glycolysis, and low dehydrogenase activities which might predispose this mammal to persistent infection. Similarities of the bat metabolism with the metabolic changes brought by SARS-CoV-2 in humans suggest possible evolution of the coronavirus targeting the host metabolic processes for its replication and survival. Further research on host-pathogen interactions at the metabolism levels would unravel the pathogenesis of coronavirus and several other viruses.
Nil
 
Date 2021-09-30T15:53:51Z
2021-09-30T15:53:51Z
2021-06-30
 
Type Article
 
Identifier Manna SK (2021) Novel coronavirus vulnerability: Metabolic derangements and altered dehydrogenase enzyme activities are central to the virus pathogenesis in human, bat and other animals. Explor Anim Med Res 11(1): 1-9. DOI : 10.52635/EAMR/11.1.1-9.
2277- 470X
http://krishi.icar.gov.in/jspui/handle/123456789/64837
 
Language English
 
Relation Not Available;
 
Publisher West Bengal Veterinary Alumni Association