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Metagenomic study focusing on antibiotic resistance genes from the sediments of River Yamuna

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Title Metagenomic study focusing on antibiotic resistance genes from the sediments of River Yamuna
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Creator Das BK
Behera BK
Chakraborty HJ
Paria P
Gangopadhyay A
Rout AK
Nayak KK
Parida PK
Rai A
 
Subject Antibiotic resistance genes Sediment metagenome Polluted riverine ecosystem Yamuna River Resistome
 
Description Not Available
Antibiotic resistance is one of the major health concerns of the present century. The direct discharge of urban sewage, hospital effluents, and pharmaceutical wastes increases the concentration of antibiotics in riverine ecosystems. This provides selection pressure for the development of novel antibiotic-resistant strains. In this study, metagenomics approach was employed a for constructing a comprehensive profile of the Antibiotic Resistance Genes (ARGs) identified in the sediments of the Yamuna River. A total of 139 ARGs were identified from 39 microbial species. Abundance analysis revealed that, aminoglycoside, beta-lactam, macrolide, and tetracycline resistance genes were highly abundant in the sediment samples obtained from the Yamuna River. The evolutionary relationships among the ARGs were studied by phylogenetic analyses, which revealed that, the identified resistome comprised eight clusters. Network analysis was performed for investigating the broad-spectrum profiles of the ARGs and their enrichment in different biological functions and pathways. Protein-protein interaction (PPI) analyses revealed that, 76, 36, 18, and 5 Gene Ontology (GO)-terms were significantly enriched in Biological process, Molecular Function, Cellular Component, and KEGG Pathways analysis, respectively. The present study elucidates the ecology of microbial antibiotic resistance in the riverine ecosystem of the Yamuna River and provides novel insights into the environmental hotspots that are amenable to the emergence of ARGs in the contaminated riverine hydrosphere.
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Date 2021-08-18T10:00:42Z
2021-08-18T10:00:42Z
2020-10-20
 
Type Research Paper
 
Identifier Das, B. K., Behera, B. K., Chakraborty, H. J., Paria, P., Gangopadhyay, A., Rout, A. K., ... & Rai, A. (2020). Metagenomic Das, B. K., Behera, B. K., Chakraborty, H. J., Paria, P., Gangopadhyay, A., Rout, A. K., ... & Rai, A. (2020). Metagenomic study focusing on antibiotic resistance genes from the sediments of River Yamuna. Gene, 758, 144951.study focusing on antibiotic resistance genes from the sediments of River Yamuna. Gene, 758, 144951.
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http://krishi.icar.gov.in/jspui/handle/123456789/58708
 
Language English
 
Relation Not Available;
 
Publisher Gene