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Curcumin has protective effect on the eye lens against arsenic toxicity.

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Title Curcumin has protective effect on the eye lens against arsenic toxicity.
Not Available
 
Creator Mohanty BP
Mitra T
Ganguly S
Das Sarkar S
Mahanty A
 
Subject Curcumin, eye lens, arsenic toxicity
 
Description Not Available
Arsenic is a highly carcinogenic environmental contaminant. Curcumin, the bioactive component of turmeric, exhibits therapeutic efficacy against several chronic inflammatory and infectious diseases. The present study was carried out to investigate the impact of arsenic on eye lens and evaluate the ameliorative potential of curcumin against arsenic toxicity. Gene expression analysis of α, β, and γ-crystallins and fatty acid profile of lens tissues of arsenic-exposed Labeo rohita was examined and the protective effect of curcumin as diet supplement was evaluated. Curcumin-supplemented diet was prepared at 1.5% and 3% and fed to four groups of fish for 7 days prior to arsenic exposure (at 5 ppm and 15 ppm) for 15 days. Gene expression analysis showed downregulation of α and β-crystallins in the eye lens of arsenic-exposed groups (fed basal diet), whereas the groups fed a curcumin-supplemented diet showed insignificant alterations. Similarly, fatty acid fingerprint of lens lipids arsenic-exposed group exhibited reduction in saturated fatty acid and docosahexaenoic acid (DHA) content. However, in 3% curcumin-supplemented diet–fed and arsenic exposed group group, fatty acid profile remained unchanged. Interestingly, concentration of one non-fatty acid, an antioxidant compound (phenol 2,4-bis 1,1 dimethyl; PD) that was identified in the GC-MS fingerprinting through NIST library (version 2.2, 2014), decreased in response to arsenic exposure which was restored to normal level in curcumin-supplemented groups proving the therapeutic potential of curcumin. The findings of the study suggest that curcumin has a protective effect on eye lens against arsenic toxicity.
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Date 2021-08-19T04:07:35Z
2021-08-19T04:07:35Z
2020-01-01
 
Type Research Paper
 
Identifier Mohanty, B. P., Mitra, T., Ganguly, S., Sarkar, S. D., & Mahanty, A. (2020). Curcumin Has Protective Effect on the Eye Lens Against Arsenic Toxicity. Biological Trace Element Research, 1-6.
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http://krishi.icar.gov.in/jspui/handle/123456789/58745
 
Language English
 
Relation Not Available;
 
Publisher Biological Trace Element Research