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<p>Design, synthesis and characterization of novel substituted pyrazol-azetidin-2-one derivatives for their antimicrobial activity</p>

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Title Statement <p>Design, synthesis and characterization of novel substituted pyrazol-azetidin-2-one derivatives for their antimicrobial activity</p>
 
Added Entry - Uncontrolled Name Srivastava, Krishna ; Faculty of Chemical Sciences, Shri Ramswaroop Memorial University Lucknow-Dewa Road, Barabanki 225 003, Uttar Pradesh, India
Singh, Raj Bahadur; Faculty of Chemical Sciences, Shri Ramswaroop Memorial University Lucknow-Dewa Road, Barabanki 225 003, Uttar Pradesh, India
Tiwari, Ram Prakash; Faculty of Chemical Sciences, Shri Ramswaroop Memorial University Lucknow-Dewa Road, Barabanki 225 003, Uttar Pradesh, India
Srivastava, Jyoti ; Department of Environmental Science, Babasaheb Bhimrao Ambedkar University, Lucknow 226 025, Uttar Pradesh, India
 
Uncontrolled Index Term Antimicrobial, Aromatic aldehyde, Antimicrobial activity, Chalcone, S. aureus, B. subtilis, β-Lactam, Elemental analysis
 
Summary, etc. <p style="text-align: justify;">A novel method is elucidated herein, describing the synthesis of novel 3-chloro-4-(2-substituted phenyl)-1-( 4'-((1-(5-( 4-substituted phenyl)-3-phenyl-4, 5-dihydro-1<em>H</em>-pyrazol-1-yl) ethylidene) amino)-[1,1'-biphenyl]-4-yl) azetidin-2-one, consisting of a pyrazol motif (prepared from chalcone) and a lactam ring ( synthesized from Schiff base of aromatic aldehyde) as a potential antimicrobial agent. The structural elucidation of the synthesized compounds have been confirmed from the elemental analysis, UV-Vis absorption spectroscopy, IR, <sup>1</sup>H NMR and mass spectral studies. The novel compounds have been subjected to <em>in vitro</em> antimicrobial screening against certain gram positive (<em>S. aureus</em>, <em>B. subtilis</em>) and gram negative (<em>P. aeruginosa</em>, <em>E. coli</em>) bacterial species. Compounds <strong>Vb</strong>, <strong>Vd</strong> and <strong>Ve</strong> are the most potent amongst all the synthesized compounds against the tested microbes.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2023-02-23 17:43:13
 
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http://op.niscair.res.in/index.php/IJC/article/view/71251
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 62, ##issue.no## 2 (2023): Indian Journal of Chemistry-(IJC)
 
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