ICAR Research Data Repository for Knowledge Management
<p>Pyridine Carboxamides Microwave-assisted solution phase synthesis of novel pyridine carboxamides in neat water and ADMET and protein-compounds interaction analysis and antibacterial activity</p>
Online Publishing @ NISCAIR
View Archive Info| Field | Value | |
| Authentication Code |
dc |
|
| Title Statement |
<p>Pyridine Carboxamides Microwave-assisted solution phase synthesis of novel pyridine carboxamides in neat water and ADMET and protein-compounds interaction analysis and antibacterial activity</p> |
|
| Added Entry - Uncontrolled Name |
Babu, Visagamoorthy ; Research & Development Centre, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India Dharman, Prabu ; Research & Development Centre, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India Basha, K Anver; P G and Research Department of Chemistry, C. Abdul Hakeem College, Melvisharam 632 509, Tamil Nadu, India |
|
| Uncontrolled Index Term |
Pyridine, Carboxamides, antibacterial activity, ADMET |
|
| Summary, etc. |
<p style="text-align: justify;">A range of novel 5-substituted-pyridine-2-carboxamides have been designed and synthesized by microwave-assisted solution phase synthesis in neat water. Their structures have been confirmed by <sup>1</sup>H NMR, <sup>13</sup>C NMR and LCMS analysis. The present work describes a simple, rapid, and efficient synthesis of compound <strong>2a</strong>-<strong>2h</strong> in good yield under mild reaction condition. Shorter reaction time and convenient workup make this methodology more practical. This protocol proceeds smoothly and avoids the use of toxic organic solvents. ADMET analysis have been performed for all the synthesized compounds and observed that all the eight compounds taken for the investigation have been shown to satisfy Lipinski's rule of 5. The molecular interaction study is performed using the AutoDock software. All the 8 test compounds are found to have higher binding affinity than the control compound chloramphenicol to the <em>E. Coli</em> DraE adhesion. In addition antibacterial activities of all eight compounds have been determined.</p> |
|
| Publication, Distribution, Etc. |
Indian Journal of Chemistry (IJC) 2023-02-23 17:43:13 |
|
| Electronic Location and Access |
application/pdf application/pdf http://op.niscair.res.in/index.php/IJC/article/view/71260 |
|
| Data Source Entry |
Indian Journal of Chemistry (IJC); ##issue.vol## 62, ##issue.no## 2 (2023): Indian Journal of Chemistry-(IJC) |
|
| Language Note |
en |
|