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Berberine derivative WJCPR11 enhances osteoblast differentiation

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Title Statement Berberine derivative WJCPR11 enhances osteoblast differentiation
 
Added Entry - Uncontrolled Name Lee, Ye Jin; Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Republic of Korea
Nam, Seo Woo; Department of Biomedical science, College of Medicine, Wonkwang University, Iksan, Republic of Korea
Park, Won-Jong ; Department of Oral and Maxillofacial Surgery, College of Dentistry, Wonkwang University, Iksan, Republic of Korea
Han, Youn Ho; Department of Oral Pharmacology, Institute of Biomaterials and Implant, and Wonkwang Dental Research Institute, College of Dentistry, Wonkwang University, Iksan, Republic of Korea
 
Uncontrolled Index Term Alkaline phosphatase; Bone morphogenetic protein 2; Bone sialoprotein; Osterix; Osteoporosis; Runx2
 
Summary, etc. Berberine is a phytocompound from plants viz. Phellodendri cortex and Coptis rhizome, used to treat a variety of diseases. It is effective in preventing osteoporosis, but it is less effective than drugs currently used in clinical practice. In this study, we used a novel berberine derivative, WJCPR11, to promote osteoblast differentiation and to investigate its use in the prevention and treatment of osteoporosis. WJCPR11 at a safe concentration without toxicity increased alkaline phosphatase (ALP) activity induced by bone morphogenetic protein 2 (BMP2) dose-dependently. The mRNA expression of ALP, osteocalcin (OC), runt-related transcription factor 2 (Runx2), and osterix was increased, with the ALP level increasing the most. In addition, the protein abundance of bone sialoprotein (BSP), collagen, type I, alpha 1, Runx2, and osterix were also increased. Moreover, the transcriptional activity of ALP, BSP, and OC was increased by WJCPR11, with OC showing the most significant increase. The results indicate that osteoblast differentiation is promoted by WJCPR11, and it could play a role in the prevention of osteoporosis.
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2023-02-24 12:56:58
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJEB/article/view/60701
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 61, ##issue.no## 03 (2023): IJEB [March 2023]
 
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