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Multi-locus genome-wide association studies (ML-GWAS)reveal novel genomic regions associated with seedling and adult plant stage leaf rust resistance in bread wheat (Triticum aestivum L.)

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Title Multi-locus genome-wide association studies (ML-GWAS)reveal novel genomic regions associated with seedling and adult plant stage leaf rust resistance in bread wheat (Triticum aestivum L.)
Not Available
 
Creator Kumar Sundeep
Vikas V.K.
Pradhan Anjan
Budhlakoti Neeraj
Mishra Dwijesh
Chandra Tilak
Bhardwaj S.C
Kumar Subodh
Sivasamy M
Jayaprakash P
R. Nisha
P. Shajitha
Peter John
Geetha, M.,
Mir Reyazul
Singh Kuldeep
 
Subject Genetics
GWAS
 
Description Not Available
Leaf rust is one of the important diseases limiting global wheat production and productivity. To identify quantitative trait nucleotides (QTNs) or genomic regions associated with seedling and adult plant leaf rust resistance, multilocus genome-wide association studies (ML-GWAS) were performed on a panel of 400 diverse wheat genotypes using 35 K single-nucleotide polymorphism (SNP) genotyping assays and trait data of leaf rust resistance. Association analyses using six multi-locus GWAS models revealed a set of 201 significantly associated QTNs for seedling and 65 QTNs for adult plant resistance (APR), explaining 1.98–31.72% of the phenotypic variation for leaf rust. Among these QTNs, 51 reliable QTNs for seedling and 15 QTNs for APR were consistently detected in at least two GWAS models and were considered reliable QTNs. Three genomic regions were pleiotropic, each controlling two to three pathotype-specific seedling resistances to leaf rust. We also identified candidate genes, such as leucine-rich repeat receptor-like (LRR) protein kinases, P-loop containing nucleoside triphosphate hydrolase and serine-threonine/tyrosine-protein kinases (STPK), which have a role in pathogen recognition and disease resistance linked to the significantly associated genomic regions. The QTNs identified in this study can prove useful in wheat molecular breeding programs aimed at enhancing resistance to leaf rust and developing next-generation leaf rust-resistant varieties.
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Date 2023-02-28T10:46:16Z
2023-02-28T10:46:16Z
2022-04-13
 
Type Research Paper
 
Identifier Not Available
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http://krishi.icar.gov.in/jspui/handle/123456789/76501
 
Language English
 
Relation Not Available;
 
Publisher Springer Nature Limited