Record Details

Association between the organic cation transporter 3 methylation and hepatocellular carcinoma

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement Association between the organic cation transporter 3 methylation and hepatocellular carcinoma
 
Added Entry - Uncontrolled Name Heidari, Zahra
Asemi-Rad, Azam
Moudi, Bita
Mahmoudzadeh-Sagheb, Hamidreza
 
Uncontrolled Index Term Hepatocellular carcinoma; Methylation; Organic cation transporters 3; Quantitative real-time PCR
 
Summary, etc. Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world and has a high death rate in the world. This research while examining the expression of OCT3 at the mRNA level has also studied gene methylation profile in patients with HCC in comparison with people without HCC. The volunteers were: patients with HCC (n=81) and a healthy control group (n=90). The expression of OCT3was studied using the qRT-PCR method. The methylation profile was evaluated by genomic DNA using methylation specific PCR (MSP) method. The expression level of OCT3 marker mRNA in patients has decreased significantly compared to healthy individuals (0.58 ± 0.311 vs 1.20 ± 0.355, P <0.001). No significant statistical relationship was found between demographic data and OCT3 expression in participants (P >0.05). The amount of methylation (UM + MM) in cancer patients has raised vs controls (P <0.001) and has increased the risk of cancer (OR=0.379, 95% CI=1.171-2.839, P <0.001, and OR=2.727, 95% CI=1.251-5.945, P <0.001, respectively).Changes in OCT3 levels appear to be associated with HCC. Also, changing the methylation pattern of this gene can reveal HCC pathology.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2023-02-28 14:31:04
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJBB/article/view/57578
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); IJBB Vol. 60 (3) [March 2023]
 
Language Note en