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Supplementation of <em>Madhuca longifolia </em>Seed oil augments diclofenac-induced organ toxicities: A biochemical and histopathological approach

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Title Statement Supplementation of <em>Madhuca longifolia </em>Seed oil augments diclofenac-induced organ toxicities: A biochemical and histopathological approach
 
Added Entry - Uncontrolled Name Simon Peter, Jerine
Nithiyanandam, Sangeetha
Katturajan, Ramkumar
Parthasarathy, Manisha
Namachivayam, Arunraj
Hiraganahalli Bhaskarmurthy, Deepak
R, Vidya
Evan Prince, Sabina
 
Uncontrolled Index Term Antioxidant; Diclofenac; Gastrointestinal toxicity; Hepatotoxicity; Madhuca longifolia seed oil; Renal toxicity
 
Summary, etc. Diclofenac medication has been extensively used for anti-inflammatory, anti-pyretic, and analgesic actions. Its abiding usage and overdose have induced toxicity and harmful effects on the liver, kidney, and gastrointestinal tract. The research aims to scrutinize the protective effect of <em>Madhuca longifolia</em> seed oil against diclofenac-induced toxicity in female Wistar albino rats. A period of 10 days of study was aimed at 7 groups; Group 1 was assigned as normal control. Group 2 has been administered diclofenac (50 mg/kg b.w. /day, i.p.) only on the last two days of each study period. Group 3 and Group 4 have been pre-treated with 1 mL, and 2 mL of <em>Madhuca longifolia</em> seed oil, respectively, and diclofenac was induced as per Group 2. Group 5 was treated with the standard drug silymarin and diclofenac. Group 6 and Group 7 were given 1 mL and 2 mL of <em>Madhuca longifolia</em> seed oil alone. After the study period, parameters like liver enzyme markers, renal enzyme markers, and antioxidants were measured, and tissue samples were analyzed for histopathological changes. The results proved that pre-treatment of 1 mL of <em>Madhuca longifolia</em> seed oil has efficacy against diclofenac-induced toxicity.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2023-02-28 14:31:04
 
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http://op.niscair.res.in/index.php/IJBB/article/view/69793
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); IJBB Vol. 60 (3) [March 2023]
 
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