Record Details

Pharmacological evaluation and kinetics of in vitro drug release efficacy of biofabricated silver nanoparticles using medicinally important Justicia neesii Ramamoorthy

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Pharmacological evaluation and kinetics of in vitro drug release efficacy of biofabricated silver nanoparticles using medicinally important Justicia neesii Ramamoorthy
 
Creator Khambhaty, Yasmin
Bondada, Suryakiran
 
Subject Antimicrobial activity
Antioxidant activity
 
Description 185-195
Green nanotechnology, the science that utilizes various plant resources for the synthesis of nanoparticles without posing
any chemical hazard has proved to be highly efficient and environment friendly technique. This opens up options for the
synthesis of novel nanoparticles with desirable characteristics required for various application viz., biosensors, biomedicine,
cosmetics, nanobiotechnology, as antimicrobials, electronics, sensing etc. In this context, here, we have made an attempt for
cost effective and eco-friendly synthesis of silver nanoparticles (AgNPs) using the extract of medicinally important plant
Justicia neesii Ramamoorthy. The phytochemical analysis of the extract exhibited the presence of glycosides, flavonoids,
lignins, phenols, phytosterols, reducing sugars, saponins, etc. The absorbance peak of the biofabricated nanoparticles at 425
nm as indicated by UV-Vis spectrophotometer broadens with increase in time indicating their poly dispersity nature and
particle size analyzer revealed the average size to be in the range of 20-45 nm. The antioxidant and antimicrobial activity of
the synthesized AgNPs demonstrated promising results. The kinetics of in vitro drug release profile of the drug loaded
AgNPs was carried out and the data obtained was correlated with various mathematical models. The drug release from
AgNPs at both the pH’s shows good fit to the First order model which is obvious from the high values of coefficient of
correlation which logically means that the release of drug from AgNPs is dependent on the concentration present within the
nanoparticles.
 
Date 2023-02-27T08:29:30Z
2023-02-27T08:29:30Z
2023-02
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/61422
https://doi.org/10.56042/ijeb.v61i03.71568
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(03) [Mar 2023]