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Protective effect of loboob (a Persian traditional remedy) on sexual hormones, antioxidant activities and stereological changes of testis tissue on busulfan induced oligospermia in rats

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Title Protective effect of loboob (a Persian traditional remedy) on sexual hormones, antioxidant activities and stereological changes of testis tissue on busulfan induced oligospermia in rats
 
Creator Jahromi, Bahia Namavar
Keshavarz, Mojtaba
Koohpeyma, Farhad
Badr, Parmis
Poordast, Tahereh
 
Subject Catalase
Follicle stimulating hormone (FSH)
Luteinizing hormone (LH)
Seminiferous tubules
Superoxide dismutase (SOD)
Testosterone
 
Description 175-184
Loboob as a traditional drug in Iranis known for its beneficial effects on busulfan-induced oligospermia. In this
experimental study, protective effects of loboob (a Persian traditional remedy) on sexual hormones, antioxidant levels and
stereological changes of testis tissue were evaluated in an oligospermia rat model induced by busulfan. Fifty male rats were randomly divided into five different groups: control, received no treatments; and the other groups administrated with a
single dose of busulfan (10 mg/kg body weight). After 30 days, these groups were treated with 0, 35, 70 or 140 mg/kg/day of loboob for 60 days. Blood samples were collected for hormone and antioxidant enzyme assays. Unbiased stereology was
performed on testis tissues to evaluate the volume of different parts of the testis and the number of various testis cells. Data
indicated that FSH, LH and MDA were increased, and testosterone, catalase, SOD were decreased in the busulfan group,
while treatment with loboob at 70 and 140 mg/kg significantly improved these parameters (P
 
Date 2023-02-27T08:34:39Z
2023-02-27T08:34:39Z
2023-02
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/61423
https://doi.org/10.56042/ijeb.v61i03.68547
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(03) [Mar 2023]