Association between the organic cation transporter 3 methylation and hepatocellular carcinoma
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Title |
Association between the organic cation transporter 3 methylation and hepatocellular carcinoma
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Creator |
Heidari, Zahra
Asemi-Rad, Azam Moudi, Bita Mahmoudzadeh-Sagheb, Hamidreza |
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Subject |
Hepatocellular carcinoma
Methylation Organic cation transporters 3 Quantitative real-time PCR |
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Description |
224-230
Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world and has a high death rate in the world. This research while examining the expression of OCT3 at the mRNA level has also studied gene methylation profile in patients with HCC in comparison with people without HCC. The volunteers were: patients with HCC (n=81) and a healthy control group (n=90). The expression of OCT3was studied using the qRT-PCR method. The methylation profile was evaluated by genomic DNA using methylation specific PCR (MSP) method. The expression level of OCT3 marker mRNA in patients has decreased significantly compared to healthy individuals (0.58 ± 0.311 vs 1.20 ± 0.355, P 0.05). The amount of methylation (UM + MM) in cancer patients has raised vs controls (P |
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Date |
2023-03-02T06:28:07Z
2023-03-02T06:28:07Z 2023-03 |
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Type |
Article
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Identifier |
0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/61468 https://doi.org/10.56042/ijbb.v60i3.57578 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJBB Vol.60(03) [March 2023]
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