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Association between the organic cation transporter 3 methylation and hepatocellular carcinoma

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Title Association between the organic cation transporter 3 methylation and hepatocellular carcinoma
 
Creator Heidari, Zahra
Asemi-Rad, Azam
Moudi, Bita
Mahmoudzadeh-Sagheb, Hamidreza
 
Subject Hepatocellular carcinoma
Methylation
Organic cation transporters 3
Quantitative real-time PCR
 
Description 224-230
Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world and has a high death rate in the world. This
research while examining the expression of OCT3 at the mRNA level has also studied gene methylation profile in patients with
HCC in comparison with people without HCC. The volunteers were: patients with HCC (n=81) and a healthy control group
(n=90). The expression of OCT3was studied using the qRT-PCR method. The methylation profile was evaluated by genomic
DNA using methylation specific PCR (MSP) method. The expression level of OCT3 marker mRNA in patients has decreased
significantly compared to healthy individuals (0.58 ± 0.311 vs 1.20 ± 0.355, P 0.05). The amount of methylation (UM + MM)
in cancer patients has raised vs controls (P
 
Date 2023-03-02T06:28:07Z
2023-03-02T06:28:07Z
2023-03
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/61468
https://doi.org/10.56042/ijbb.v60i3.57578
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.60(03) [March 2023]