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Supplementation of Madhuca longifolia Seed oil augments diclofenac-induced organ toxicities: A biochemical and histopathological approach J

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Title Supplementation of Madhuca longifolia Seed oil augments diclofenac-induced organ toxicities: A biochemical and histopathological approach J
 
Creator Simon, Jerine Peter
Nithiyanandam, Sangeetha
Katturajan, Ramkumar
Parthasarathy, Manisha
Namachivayam, Arunraj
Bhaskarmurthy, Deepak Hiraganahalli
R, Vidya
Prince, Sabina Evan
 
Subject Antioxidant
Diclofenac
Gastrointestinal toxicity
Hepatotoxicity
Madhuca longifolia seed oil
Renal toxicity
 
Description 186-195
Diclofenac medication has been extensively used for anti-inflammatory, anti-pyretic, and analgesic actions. Its abiding
usage and overdose have induced toxicity and harmful effects on the liver, kidney, and gastrointestinal tract. The research
aims to scrutinize the protective effect of Madhuca longifolia seed oil against diclofenac-induced toxicity in female Wistar
albino rats. A period of 10 days of study was aimed at 7 groups; Group 1 was assigned as normal control. Group 2 has been
administered diclofenac (50 mg/kg b.w. /day, i.p.) only on the last two days of each study period. Group 3 and Group 4 have
been pre-treated with 1 mL, and 2 mL of Madhuca longifolia seed oil, respectively, and diclofenac was induced as per
Group 2. Group 5 was treated with the standard drug silymarin and diclofenac. Group 6 and Group 7 were given 1 mL and
2 mL of Madhuca longifolia seed oil alone. After the study period, parameters like liver enzyme markers, renal enzyme
markers, and antioxidants were measured, and tissue samples were analyzed for histopathological changes. The results
proved that pre-treatment of 1 mL ofMadhuca longifolia seed oil has efficacy against diclofenac-induced toxicity.
 
Date 2023-03-02T07:02:48Z
2023-03-02T07:02:48Z
2023-03
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/61471
https://doi.org/10.56042/ijbb.v60i3.69793
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.60(03) [March 2023]