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Green synthesis of 5-methylpyridinium derivatives by C2-functionalization of pyridine-1-oxide derivatives and their antibacterial activity

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Title Statement Green synthesis of 5-methylpyridinium derivatives by C2-functionalization of pyridine-1-oxide derivatives and their antibacterial activity
 
Added Entry - Uncontrolled Name Dhadda, Surbhi ; Department of Chemistry, Vivekananda Global University, Jagatpura, Jaipur 303 012, India
Goswami, Prakash G; Centre of Advanced Studies, Department of Chemistry, University of Rajasthan, Jaipur 302 004, India
Yadav, Kalpana ; Centre of Advanced Studies, Department of Chemistry, University of Rajasthan, Jaipur 302 004, India
Guleria, Anjali ; Centre of Advanced Studies, Department of Chemistry, University of Rajasthan, Jaipur 302 004, India
Jangid, Dinesh K; Centre of Advanced Studies, Department of Chemistry, University of Rajasthan, Jaipur 302 004, India
Khandelwal, Chandra L; Centre of Advanced Studies, Department of Chemistry, University of Rajasthan, Jaipur 302 004, India
 
Uncontrolled Index Term Multicomponent reaction, C2-Functionalization, Pyridine-1-oxide, Ionic liquid, Green economic route, Antibacterial activity
 
Summary, etc. <p style="text-align: justify;">An innovative green economic route has been developed for one pot multicomponent synthesis of 5-methylpyridinium derivatives by the reaction of 3-methylpyridine-1-oxide, aromatic aldehyde and β-ketoester catalysed by different ionic liquids (ILs), [BMIM][OH], [BMIM][Cl], [BMIM][Ac] in good to excellent yields. A relative study reinforced that [BMIM][OH] is the best IL for this C2-functionsalization reaction. The main highlights of this synthetic protocol are simple work-up, cost effectiveness and environmentally benign processing. The synthesized derivatives have been assessed for possible antibacterial activity against <em>Staphylococcus aureus </em>and <em>Escherichia coli</em> by using the microdilution method. The results of antibacterial activity suggests that compound <strong>4I</strong> shows best antibacterial activity and other compounds show good to moderate activity.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2023-03-17 15:15:07
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/71997
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 62, ##issue.no## 3 (2023): Indian Journal of Chemistry-(IJC)
 
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