Record Details

<p>New quinazolinone-based Mannich bases: Synthesis and <em>in vitro</em> cytotoxic evaluation</p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p>New quinazolinone-based Mannich bases: Synthesis and <em>in vitro</em> cytotoxic evaluation</p>
 
Added Entry - Uncontrolled Name Minh, Nguyen Van; School of Chemical Engineering, Hanoi University of Science and Technology No 1, Dai Co Viet, Hai Ba Trung, Ha Noi, Viet Nam
Thao, Nguyen Thi Phuong; School of Chemical Engineering, Hanoi University of Science and Technology No 1, Dai Co Viet, Hai Ba Trung, Ha Noi, Viet Nam
Linh, Nguyen Pham Duy; School of Chemical Engineering, Hanoi University of Science and Technology No 1, Dai Co Viet, Hai Ba Trung, Ha Noi, Viet Nam
Vu, Tran Khac; School of Chemical Engineering, Hanoi University of Science and Technology No 1, Dai Co Viet, Hai Ba Trung, Ha Noi, Viet Nam
 
Uncontrolled Index Term Cancer, Mannich, Cytotoxicity, Quinazolinone
 
Summary, etc. <p style="text-align: justify;">This research presents the synthesis of new quinazolinone-based Mannich bases in good yields <em>via</em> a three-step procedure. The first step is the reaction of 6-hydroxyanthranilic acid <strong>1</strong> with an excess of acetic anhydride at 150°C for 2 h to afford benzoxazinone <strong>2</strong> in 87% yield. Compound <strong>2</strong> is then reacted with 4-aminophenol in DMSO at reflux for 7 h to give compound <strong>3 </strong>in 75% yield. Finally, the reaction of <strong>3</strong> with paraformadehyde and secondary amines in ethanol affords new quinazolinone-based Mannich bases <strong>4a-c</strong> and <strong>5a-e</strong> in 55-70% yields. The structure of Mannich bases have been characterized by NMR and MS spectra. The bio-assay results show that some new Mannich bases exhibited weak to moderate cytotoxic activity against SKLu-1 and MCF-7 cell lines.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2023-03-17 15:15:07
 
Electronic Location and Access application/pdf
application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/71995
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 62, ##issue.no## 3 (2023): Indian Journal of Chemistry-(IJC)
 
Language Note en