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Biodegradable curative film for medical application

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Title Biodegradable curative film for medical application
 
Creator Ganesan, P
 
Subject Antimicrobial
Biodegradable film
Biopolymer
Chitosan
Silk fibroin
Wound healing
 
Description 52-60
An attempt has been made to produce a herbal based silk fibroin – chitosan biodegradable film. Herbs are used for
wound healing purpose, silk fibroin for its remarkable bio-medical and mechanical properties and chitosan for its
antimicrobial properties. Herbal extracts, such as Aloe barbadensis Mill, (Aloe Vera), Cissus quadrangularis (Pirandai), and
Curcuma longa (Turmeric) have been used to impart wound healing effects. The physical and antimicrobial properties have
been studied as per the standard methods. The cytotoxic reactivity of the test, and control sample are evaluated under an
inverted phase contrast microscope based on the standard. Scanning electron microscope is used to study the morphology of
prepared film for process versatility and highly specific surface area. The chemical compound assessments are studied by
Fourier Transform Infrared. Microbial growth under the bio films is found to be absent, and test results show better activity
against Escherichia coli and Staphylococcus aureus. The blended film shows none cytotoxic reactivity to fibroblast cells and
test silk fibroin blended film shows slight cytotoxic reactivity to fibroblast cells after 24 h contact. The achievement of
numerical more than 2 is considered as cytotoxic effect. Since the film samples achieve a numerical grade not greater than 2,
the samples are considered as non cytotoxic. Microbial growth under the bio films is found to be absent and test results show
better activity against Escherichia coli.
 
Date 2023-03-17T07:13:28Z
2023-03-17T07:13:28Z
2023-03
 
Type Article
 
Identifier 0975-1025 (Online); 0971-0426 (Print)
http://nopr.niscpr.res.in/handle/123456789/61533
https://doi.org/10.56042/ijftr.v48i1.46502
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJFTR Vol.48(1) [March 2023]